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EC number: 305-998-4 | CAS number: 95465-85-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Bioaccumulation potential is not relevant since fatty acids, C14-18 + C16-18, unsatd. are natural fatty acids produced from animal and vegetable fats, which are part of the typical European diet. Long-chain carboxylic acids are readily absorbed as micelle aggregates, esterified with glycerol in chylomicrons and very low density lipoproteins, and transported via the lymphatic system. fatty acids, C14-18 + C16-18, unsatd. can either be stored in the form of triglycerides (98% of which occurs in adipose tissue depots) or they can be oxidised for energy via the β-oxidation and tricarboxylic acid cycle pathways of catabolism.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Information taken from HERA (2002):
Fatty acids and their salts
Fatty acids are an endogenous part of every living cell and are an essential dietary requirement. They are absorbed, digested, and transported in animals and humans. Proposed mechanisms for fatty acid uptake by different tissues range from passive diffusion to facilitated diffusion or a combination of both (Abumrad et al. 1984; Harris et al., 1980). Radioactivity from labelled fatty acids administered orally, intravenously, intraperitoneally, and intraduodenally has been found in various tissues and in blood and lymph (CIR, 1987).
Fatty acids taken up by the tissues can either be stored in the form of triglycerides (98% of which occurs in adipose tissue depots) or they can be oxidised for energy via the β-oxidation and tricarboxylic acid cycle pathways of catabolism (Masoro, 1977). The β-oxidation of fatty acids occurs in most vertebrate tissues utilising an enzyme complex for the series of oxidation and hydration reactions resulting in the cleavage of acetate groups as acetyl CoA. β-oxidation essentially reduces the alkyl chain length by 2 carbon atoms with the release of acetic acid. This leaves another carboxyl group on the shortened alkyl chain for subsequent further β-oxidation. An additional isomerisation reaction is required for the complete catabolism of oleic acid. Alternate oxidation pathways can be found in the liver (ω-oxidation) and the brain (α-oxidation) (CIR, 1987).
Long chain, saturated fatty acids are less readily absorbed than unsaturated or short chain acids. Stearic acid is the most poorly absorbed of the common fatty acids (Clayton & Clayton, 1982; Opdyke, 1979). Several investigators have also found increasing fatty acid chain length slightly decreased their digestibility (CIR, 1987).
Howes (1975) examined the turnover of [14C] surfactants in the rat and found that at 6h after administration, the C10 and C12 soaps were readily metabolised and the main route of excretion was as 14CO2. The C14 soap was readily incorporated into the body and the 14C excretion was slow. The C16 and C18 soaps showed some metabolism with subsequent 14CO2 excretion but most of the 14C was recovered in the carcass at 6 hours.
Dermal Penetration
It has been shown that the greatest skin penetration of the human epidermis was with C10 and C12 soaps and the rate of percutaneous absorption of sodium laurate is greater than that of most other anionic surfactants. (Prottey and Ferguson, 1975; Madsen et al., 2001; Howes, 1975).
Howes (1975) studied the percutaneous absorption of some anionic surfactants and showed that sodium decanoate was reportedly poorly absorbed through the skin of rats when in uncovered contact for 15 minutes. Penetration through excised human skin proceeded at a rate similar to that for excised rat skin for up to 6 hours; thereafter absorption through human skin was slightly quicker. Also, for the three soaps which penetrated the skin (C10, C12 and C14) there was a lag time of 1 hour before any measurable penetration occurred, but after this the rate of penetration steadily increased. Howes also calculated from human epidermal studies in vitro that only small amounts of the C10, C12 and C14 soaps would be likely to penetrate the skin from a 15 minute wash and rinse in vivo. The low penetration rates of the C16 and C18 soaps suggests that little or none of these would penetrate from a 15 minute wash and rinse in vivo.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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