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EC number: 932-121-8 | CAS number: 1147459-12-8
Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic ecotoxicity tests of N-[3-(dimethylamino)propyl]-C12-18(even numbered)-alkylamide
on daphnia and algae have been performed in natural river water. This approach is considered to be conservative but more environmentally realistic than the standard method. Indeed, the substance has a strong tendency to adsorb to negatively charged surfaces (suspended matter, algae, test vessels or organic material). Ecotoxicity tests performed in river water using the bulk approach reduce the bioavailability of the test substance as it occurs in the environment with such substances.Toxicity to fish:
The study from Akzo Nobel, 2004 (OECD 203, static conditions) reported a LC50_96h of 0.58 mg/L for zebra fish. The test substance was considered as very toxic to fish. The validity criteria were fulfilled but the quantification of the applied concentrations was not performed. Thus the test was considered as valid with restrictions.
Toxicity to invertebrates:
A long-term aquatic toxicity study on Daphnia magna (OECD 211) performed with a bulk approach in river water is available (Kean, 2013). The 28d-EC50 based on immobilization under semi-static conditions was 0.5 mg/L and was used as a worst-case for the acute toxicity. And the 28d-EC10 based on reproduction was 0.28 mg/L.
Toxicity to aquatic algae:
Toxicity to green algae was evaluated in the study from Kean (2010).
This study was carried out in general accordance with OECD Guideline 201 using some specific modifications (natural surface water supplemented with nutrients and NaHCO3). The bulk approach was applied to the test methodology allowing the use of total aquatic concentrations for calculation of endpoints. The 72 hour ErC10 was calculated as 0.015 mg/L and the ErC50 as 0.086 mg/L. Thus the substance is considered as very toxic to algae.
Toxicity to microorganisms:
Ready biodegradability of N-[3-(dimethylamino)propyl]-C12-18(even numbered)-alkylamide has been performed according to the OECD guideline 301 D “Ready biodegradability - Closed Bottle Test” and GLP requirements (Van Ginkel, 2009). Under the test conditions, the percentage of biodegradation of 2 mg/L of test item reached 85 % at the end (28 days) of the test. Thus it can be concluded that the test substance is not inhibitory to micro-organisms at 2 mg/L.
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