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Diss Factsheets
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EC number: 231-977-3 | CAS number: 7783-06-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Immunotoxicity
Administrative data
- Endpoint:
- immunotoxicity
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Effect of hydrogen sulfide on bacterial inactivation in the rat lung
- Author:
- Rogers RE and Ferin J
- Year:
- 1 981
- Bibliographic source:
- Arch. Environ. Health, 36(5), 261-264
- Reference Type:
- publication
- Title:
- Effect of in vitro exposure to hydrogen sulfide on rabbit alveolar macrophages cultured on gas-permeable membranes
- Author:
- Robinson AV
- Year:
- 1 982
- Bibliographic source:
- Environ. Res. 27(2):491-500
- Reference Type:
- secondary source
- Title:
- TOXICOLOGICAL REVIEW OF HYDROGEN SULFIDE (CAS No. 7783-06-4). In Support of Summary Information on the Integrated Risk Information System (IRIS)
- Author:
- U.S. Environmental Protection Agency
- Year:
- 2 003
- Bibliographic source:
- EPA/635/R-03/005. www.epa.gov/iris
Materials and methods
Test material
- Reference substance name:
- Hydrogen sulphide
- EC Number:
- 231-977-3
- EC Name:
- Hydrogen sulphide
- Cas Number:
- 7783-06-4
- Molecular formula:
- H2S
- IUPAC Name:
- hydrogen sulfide
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
The effects of H2S on lung bacterial defense has been investigated. Male Long-Evans rats were exposed to 45 ppm (636 mg/m3) H2S for 2, 4, or 6 hr followed by bacterial challenge to Staphylococcus epidermidis. In control animals, most of the bacteria was inactivated by the 6-hour postchallenge sacrifice time. Rats exposed to H2S for 2 hours responded similarly to controls. However, rats exposed to H2S for 4 and 6 hours had 6.5- and 52-fold greater percent bacteria remaining, respectively, compared to controls. The investigators suggest that an H2S-induced absence of bacterial inactivation may explain secondary pneumonias in humans subsequent to acute or subacute H2S exposure. The effect of bacterial inactivation was hypothesized by the investigators to be due to alveolar macrophage inactivation. The hypothesis is supported by Robinson (1982) who demonstrated that rabbit alveolar macrophages lost the phagocytic ability in vitro when exposed to 54 ppm (75 mg/m3) H2S for 24 hours.
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