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Diss Factsheets
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EC number: 203-213-9 | CAS number: 104-55-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritative data base
- Title:
- HSDB Number 209
- Year:
- 2 011
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC
- Reference Type:
- other: Authoritative data base
- Title:
- No information
- Year:
- 2 012
- Bibliographic source:
- NTP (National Toxicological Program)by Agency for Toxic Substances and Disease Registry; Division of Toxicology/Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, Georgia 30333
Materials and methods
- Objective of study:
- excretion
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from HSDB & NTP
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cinnamaldehyde
- EC Number:
- 203-213-9
- EC Name:
- Cinnamaldehyde
- Cas Number:
- 104-55-2
- Molecular formula:
- C9H8O
- IUPAC Name:
- 3-phenylacrylaldehyde
- Test material form:
- liquid: viscous
- Details on test material:
- - Name of test material (as cited in study report): cinnamaldehyde
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Duration and frequency of treatment / exposure:
- 7 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5, 50, or 500 mg/kg bw
- No. of animals per sex per dose / concentration:
- 8/group
- Details on dosing and sampling:
- Twenty-four hours later, animals in each group received a single oral dose of [3-(14)C]cinnamaldehyde equivalent to the pretreatment level. At 50 and 500 mg/kg bw, radioactivity could be measured in animals terminated 3 days after dosing.
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Cinnamaldehyde is easy absored within the body rapidly and further distributed in various organs
- Type:
- distribution
- Results:
- Radioactivity is distributed primarily to the gastrointestinal tract, kidneys, and liver, after single- or multiple-dose oral administration. At all dose levels, a small amount of the dose is distributed to the fat.
- Type:
- metabolism
- Results:
- In the high dose pretreatment group, benzoic acid is the major metabolite, suggesting that saturation of the glycine conjugation pathway occurs at repeated high dose levels of cinnamaldehyde.
- Type:
- excretion
- Results:
- After 24 hr, >80% of the radioactivity is recovered in the urine and <7% in the feces from all groups of rats, regardless of dose level.
Toxicokinetic / pharmacokinetic studies
- Details on distribution in tissues:
- Radioactivity is distributed primarily to the gastrointestinal tract, kidneys, and liver, after single- or multiple-dose oral administration. At all dose levels, a small amount of the dose is distributed to the fat.
- Details on excretion:
- After 24 hr, >80% of the radioactivity is recovered in the urine and <7% in the feces from all groups of rats, regardless of dose level.
Metabolite characterisation studies
- Details on metabolites:
- Except for the high dose pretreatment group, the major urinary metabolite is hippuric acid, accompanied by small amounts of cinnamic and benzoic acid. In the high dose pretreatment group, benzoic acid is the major metabolite, suggesting that saturation of the glycine conjugation pathway occurs at repeated high dose levels of cinnamaldehyde.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Based on the study conducted on male rat on cinnamaldehyde by oral route the toxicokinetcs are found be as follows
Absorption:
Cinnamaldehyde is easy absored within the body rapidly and further distributed in various organs
Dirtibution:
Radioactivity is distributed primarily to the gastrointestinal tract, kidneys, and liver, after single- or multiple-dose oral administration. At all dose levels, a small amount of the dose is distributed to the fat.
Metabolism:
In the high dose pretreatment group, benzoic acid is the major metabolite, suggesting that saturation of the glycine conjugation pathway occurs at repeated high dose levels of cinnamaldehyde.
Execrition
After 24 hr, >80% of the radioactivity is recovered in the urine and <7% in the feces from all groups of rats, regardless of dose level. - Executive summary:
Based on the study conducted on male rat on cinnamaldehyde by oral route the toxicokinetcs are found be as follows
Absorption:
Cinnamaldehyde is easy absored within the body rapidly and further distributed in various organs
Dirtibution:
Radioactivity is distributed primarily to the gastrointestinal tract, kidneys, and liver, after single- or multiple-dose oral administration. At all dose levels, a small amount of the dose is distributed to the fat.
Metabolism:
In the high dose pretreatment group, benzoic acid is the major metabolite, suggesting that saturation of the glycine conjugation pathway occurs at repeated high dose levels of cinnamaldehyde.
Execrition
After 24 hr, >80% of the radioactivity is recovered in the urine and <7% in the feces from all groups of rats, regardless of dose level.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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