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Diss Factsheets
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EC number: 203-906-6 | CAS number: 111-77-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- Toxtree (Estimation of Toxic Hazard - a Decision Tree Approach) v. 2.6.6 Software for estimation of toxic hazard by applying a decision tree approach Ideaconsult Ltd
- Author:
- Ideaconsult
- Year:
- 2 016
- Bibliographic source:
- http://toxtree.sourceforge.net
Materials and methods
- Principles of method if other than guideline:
- QSAR method
Test material
- Reference substance name:
- 2-(2-(2-butoxyethoxy)ethoxy)ethanol
- EC Number:
- 205-592-6
- EC Name:
- 2-(2-(2-butoxyethoxy)ethoxy)ethanol
- Cas Number:
- 143-22-6
- Molecular formula:
- C10H22O4
- IUPAC Name:
- 2-[2-(2-butoxyethoxy)ethoxy]ethanol
- Reference substance name:
- 205-22-6
- IUPAC Name:
- 205-22-6
- Reference substance name:
- 2-(2-(2-butoxy)ethoxy)ethanol
- IUPAC Name:
- 2-(2-(2-butoxy)ethoxy)ethanol
- Details on test material:
- Name of test material (as cited in study report): 2-(2-(2-butoxy)ethoxy)ethanol
Analytical purity: purity 79.5%
Constituent 1
Constituent 2
Constituent 3
- Specific details on test material used for the study:
- CCCCOCCOCCOCCO
Results and discussion
Test results
- Remarks on result:
- other: Structural alert for .H-acceptor-path3-H-acceptor.
Any other information on results incl. tables
QSA1.Acyl halides No
CCCCOCCOCCOCCO
QSA2.Alkyl (C5) or benzyl ester of sulphonic or phosphonic acid No
CCCCOCCOCCOCCO
QSA3.N-methylol derivatives No
CCCCOCCOCCOCCO
QSA4.Monohaloalkene No
CCCCOCCOCCOCCO
QSA5.S or N mustard No
CCCCOCCOCCOCCO
QSA6.Propiolactones and propiosultones No
CCCCOCCOCCOCCO
QSA7.Epoxides and aziridines No
CCCCOCCOCCOCCO
QSA8.Aliphatic halogens No
CCCCOCCOCCOCCO
QSA9.Alkyl nitrite No
CCCCOCCOCCOCCO
QSA10.α,β unsaturated carbonyls No
CCCCOCCOCCOCCO
QSA11.Simple aldehyde No
CCCCOCCOCCOCCO
QSA12.Quinones No
CCCCOCCOCCOCCO
QSA13.Hydrazine No
CCCCOCCOCCOCCO
QSA14.Aliphatic azo and azoxy No
CCCCOCCOCCOCCO
QSA15.Isocyanate and isothiocyanate groups No
CCCCOCCOCCOCCO
QSA16.Alkyl carbamate and thiocarbamate No
CCCCOCCOCCOCCO
QSA18.Polycyclic Aromatic Hydrocarbons No
CCCCOCCOCCOCCO
QSA19.Heterocyclic Polycyclic Aromatic Hydrocarbons No
CCCCOCCOCCOCCO
QSA21.Alkyl and aryl N-nitroso groups No
CCCCOCCOCCOCCO
QSA22.Azide and triazene groups No
CCCCOCCOCCOCCO
QSA23.Aliphatic N-nitro No
CCCCOCCOCCOCCO
QSA24.α,β unsaturated alkoxy No
CCCCOCCOCCOCCO
QSA25.Aromatic nitroso group No
CCCCOCCOCCOCCO
QSA26.Aromatic ring N-oxide No
CCCCOCCOCCOCCO
QSA27.Nitro aromatic No
CCCCOCCOCCOCCO
QSA28.Primary aromatic amine, hydroxyl amine and its derived esters
(with restrictions) No
CCCCOCCOCCOCCO
QSA28bis.Aromatic mono- and dialkylamine No
CCCCOCCOCCOCCO
QSA28ter.Aromatic N-acyl amine No
CCCCOCCOCCOCCO
QSA29.Aromatic diazo No
CCCCOCCOCCOCCO
QSA30.Coumarins and Furocoumarins No
CCCCOCCOCCOCCO
QSA32.1,3-dialkoxy-benzene No
CCCCOCCOCCOCCO
QSA33.1-phenoxy-benzene No
CCCCOCCOCCOCCO
QSA34.H-acceptor-path3-H-acceptor Yes
CCCCOCCOCCOCCO
QSA35.Oxolane No
CCCCOCCOCCOCCO
QSA36.Carbodiimides No
CCCCOCCOCCOCCO
QAny alert?.At least one alert fired? Yes Class At
least one positive structural alerts for the micronucleus assay (Class I)CCCCOCCOCCOCCO
Applicant's summary and conclusion
- Executive summary:
A valid QSAR model based on the Toxtree ISS rulebase of alerts for the in vitro mouse micronucleus assay predicted that
the substance had an alert for QSA34 for H-acceptor-path3-H-acceptor, otherwise there were no other alerts triggered.
It should be noted that all other glycol ethers with the structure R[OCC]xO, where R is any alkyl chain from methyl upwards and x is any integer from 1 upwards , produces identical results from this QSAR. Clearly, based on the negative in vivo experimental data, this is a false positive.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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