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EC number: 233-343-1 | CAS number: 10124-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20/10/1992-22/10/1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 797.1300 (Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids)
- Deviations:
- yes
- Remarks:
- One concentration and a no-treatment control were tested in triplicate
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: samples were collected from the control treatment groups at 0 and 48 hrs.
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances):
- Controls: vehicle
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): filtered (milli-Q filter) deionized, well water - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna (water flea)
- Source: Stock cultures maintained at ESE.
- Age at study initiation (mean and range, SD): <24hr
- Feeding during test - no
- Food type (pre-test): YTC (synthetic food composed of yeast, trout chow and cereal leaves) - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Post exposure observation period:
- No
- Hardness:
- 167 mg/L as CaCO3 at 0h
- Test temperature:
- 20 ± 2°C
- pH:
- Control test: 8.3-8.4 (measured at 0, 24 and 48hr)
Test substance: 7.3-8.2 (measured at 0, 24, 48hr) - Dissolved oxygen:
- Control test: 8.3-8.4 mg/L (measured at 0, 24 and 48hr)
Test substance: 8.3-8.5 mg/L (measured at 0, 24, 48hr) - Salinity:
- Not applicable
- Nominal and measured concentrations:
- Control:
nominal concentration: 0 mg/L
mean measured concentration: <0.06 mg/L
Test:
nominal concentration: 500 mg/L
mean measured concentration: 485 ± 2.8 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: cylindical, glass, exposure chambers ( 100 mm diameter X 50 mm height)
- Type: closed
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 3
- No. of vessels per vehicle control (replicates): 3
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Milli-Q water. Pumped from a deep well and passed through activated charcoal, cation, anion and mixed beds and then through the Milli-Q system prior to use. Sample was collected on April 29, 1992.
- Total organic carbon: <1.0 mg/L
- Metals:
arsenic: <2.3 µg/L
aluminium: <42.9 µg/L
cadmium: <0.2 µg/L
calcium: 0.073 mg/L
chromium: <7.4 µg/L
cobalt: <18 µg/L
copper: <3.8 µg/L
iron: <10.1 µg/L
mercury: 0.18 µg/L
magnesium: <0.037 µg/L
nickel: <17.4 µg/L
selenium: <2.0 µg/L
silver: <6.1 µg/L
sodium: <0.162 µg/L
zinc: <6.5 µg/L
- Pesticides:
Pesitcides-Organochlorine & PCB's: <0.006 µg/L
Pesticides-Organophosphate: <2.94 µg/L
- Alkalinity: 6.0 mg/L as CaCO3
OTHER TEST CONDITIONS
- Photoperiod: 16-hours light and 8-hours dark with a 15 minute dawn/dusk transition
- Light intensity: no data
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Test organisms were observed daily for immobilisation (upon prodding) and any behavioural changes , and paralysed organisms removed.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: not applicable
- Justification for using less concentrations than requested by guideline: In a range-finding test, 500 mg test substance/L of exposure water was not acutely toxic to the test organisms.
- Range finding study
- Test concentrations: up to 500 mg/L
- Results used to determine the conditions for the definitive study: no data - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 485 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- other: analysis of total phosphates and conversion factor from total phosphate to sodium hexametaphosphate
- Basis for effect:
- mobility
- Remarks:
- immobilisation
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- Not applicable
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance, sodium hexametaphosphate, was not acutely toxic to the water flea, Daphnia magna, at a mean measured concentration of 485 mg/L.
This study is conducted according to an appropriate guideline and under the conditions of GLP and therefore the study is considered to be acceptable and to adequately satisfy both the guideline requirement and the regulatory requirement as a key study for this endpoint.
Reference
Table 2: Immobility of water fleas (D. magna) exposed to sodium hexametaphosphate in a 48-hr static , acute toxicity test.
Mean measured concentration of sodium hexametaphosphate (mg/L) |
Cumulative number of immobilised organisms and Percent mortality (parenthic value) |
|
24 hr |
48 hr |
|
<0.06 (control) |
0(0) |
0(0) |
485 |
0(0) |
0(0) |
Description of key information
Two studies are available to assess the short-term toxicity of sodium metaphosphate to aquatic invertebrates. The key study (Yurk, 1993) has been conducted to an appropriate guideline and under the conditions of GLP.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
The test substance, sodium hexametaphosphate, was not acutely toxic to the water flea, Daphnia magna, at a mean measured concentration of 485 mg/L.
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