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EC number: 629-850-6 | CAS number: 1245638-61-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
The substance is irritating to skin and highly irritating to eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin
A study was performed to assess the irritation potential of PETIA to rabbit skin according to a method equivalent or similar to OECD Guideline 404. 0.5 mL was applied to the intact and abraded skin under gauze pads and was covered with 'Elastoplast' elastic adhesive dressing backed with 'Sleek' waterproof strapping for 24 h. After 24 h of exposure, PETIA was removed and the animals were scored for irritation reactions at 24 and 72 h post-application. Very slight to well-defined erythema with very slight to moderate oedema was observed at 24 h post-application at intact and abraded sites in all animals. At 72 h reading, reactions had gradually ameliorated in four animals when very slight to well-defined erythema with or without very slight to slight oedema were seen. Well-defined erythema with slight to moderate oedema was seen in two animals. A necrotic patch or edge was seen at two intact and one abraded site. In conclusion, under the conditions of the study, the primary skin irritation score of the substance was calculated to be 3.29 (Parcell, 1997).
A study was performed to assess the irritation potential of PETIA to rabbit skin according to method described in the Code of Federal Regulations, Title 16, Section 1500.41. 0.5 mL of the test material was applied to the intact and abraded skin under gauze pads and wrapped with an impervious material such as a rubberized cloth for 24 h. After 24 h of exposure, the substance was removedand the animals were scored for irritation reactions at 24 and 72 h post-application. Very slight to well-defined erythema with very slight to severe oedema was observed in all animals at 24 and 72 h post-application. Blanching of the skin was observed in one intact and two abraded sites and scab formation was present in one intact site. Under the conditions of the study, the primary skin irritation index of the test substance was calculated to be 4.3 (Kynoch and Ligett, 1977).
A study was performed to assess the irritation potential of SN-1716 rabbit skin according to a method equivalent or similar to OECD Guideline 404 (Acute Dermal Irritation / Corrosion). 0.5 mLwas applied to the intact and abraded skin under gauze pads and wrapped with impervious plastic sheeting for 24 h. After 24 h of exposure, the substance was removed and the animals were scored for skin irritationreactions at 24 and 72 h post-application. Very slight to well-defined erythema with very slight to severe oedema was observed in animals at 24 and 72 h post-application. Second degree chemical burns (score of 4) were observed at abraded site at 24 h post-application in four animals. Third degree chemical burn (score of 4) was observed at intact site at 72 h post-application in one animal. In conclusion, under the conditions of the study, the primary irritation score of the test substance was calculated to be 5.0 (Trzyna and Paa, 1976).
A study was performed to assess the irritation potential of SN-1777 to rabbit skin according to a method equivalent or similar to OECD Guideline 404. 0.5 mL was applied to the intact and abraded skin under gauze pads and wrapped with impervious plastic sheeting for 24 h. After 24 h of exposure, the substance was removed and the animals were observed for skin reactions at 24 and 72 h post-application. Very slight to well-defined erythema with very slight to well-defined oedema was observed in animals at 24 and 72 h post-application. Second degree chemical burns (score of 4) was observed at abraded site of application in two animals. Under the conditions of the study, the primary skin irritation score of the substance was calculated to be 2.5 (Baker, 1976).
Eye
A study was conducted to evaluate the eye irritation potential of C-171 in rabbit eyes. The study performed was similar to OECD Guideline 405. 0.1 mL of the substance was instilled into the right eye of nine rabbits; the left eye served as an untreated control. One group of six rabbits received no further treatment. In the second group, three rabbits eyes were rinsed 20 s post-instillation for 60 s. Irritation was scored by the Draize scoring system at 24, 48 and 72 h and 4, 7, 9, 11 and 14 d post-instillation. The substance caused extensive eye damage. Response was so severe that many parameters in animals with non-rinsed eyes could not be evaluated: these animals were sacrificed at Day 7 for humane reasons. Animals with rinsed eyes exhibited positive scores for all parameters (conjunctival redness, chemosis, necrosis and ulceration, corneal opacity and ulceration, and iridial damage). All three animals exhibited pannus and continued to exhibit signs of irritation at termination of the observation period (Day 14). In conclusion, under the conditions of the study, the test substance was found to be highly irritating to the rabbit eye (Auletta, 1980b).
A study was performed to assess the eye irritation potential of SN-1716 to rabbits according to a method equivalent or similar to OECD Guideline 405 (Acute Eye Irritation / Corrosion). 0.1 mL was instilled into the conjuctival sac of the right eye of each rabbit.The left eye of each rabbit served as a control. Unrinsed, the eyes were scored (Draize scoring system) for irritation reactions at 1, 24, 48 and 72 h, 7 and 14 d post-instillation. Average cornea score was observed to be 20, 40, 40, 73.3 and 80 at 24, 48 and 72 h, 7 and 14 d, respectively. Average iris score was observed to be 5, 5, 5, 8.3 and 9.2 at 24, 48 and 72 h, 7 and 14 d, respectively. Average conjunctiva score was observed to be 16, 20, 20, 20, 20 and 20 at 1, 24, 48 and 72 h, 7 and 14 d, respectively. In conclusion, under the conditions of the study, the eye irritation score of the test substance was calculated to be 109.2 / 110. The test substance was found to be highly irritating to eyes (Trzyna and Paa, 1976).
Justification for selection of skin irritation / corrosion endpoint:
Several studies available showing skin irritation.
Justification for selection of eye irritation endpoint:
Several studies available showing eye irritation.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: highly irritating
Justification for classification or non-classification
In studies conducted in rabbits, PETIA was moderately irritating to skin and highly irritating to eyes, with effects on the cornea, iris and conjunctivae not reversible within 14 days. Hence, it qualifies for classification as Skin Irrit. 2 – H315 (causes skin irritation) and Eye Damage 1 - H318 (causes serious eye damage) according to EU CLP (EC 1272/2008) criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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