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EC number: 235-804-2 | CAS number: 12767-90-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28/08/1990 - 19/10/1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- other: federal Insecticide, Fungicide and Rodenticide Act (40 CFR)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: Toxic Substances Control Act (40 CFR)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Hexaboron dizinc undecaoxide
- EC Number:
- 235-804-2
- EC Name:
- Hexaboron dizinc undecaoxide
- Cas Number:
- 12767-90-7
- Molecular formula:
- B6O11Zn2
- IUPAC Name:
- hexaboron dizinc undecaoxide
- Details on test material:
- - Name of test material: XPI-187 Zinc Borate
- Substance type: Inorganic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:King's Wheel Rabbitry
- Age at study initiation: Young adult
- Weight at study initiation: 2256 - 2438 g
- Housing: Singly in wire mesh suspension cages
- Diet: Ad libitum
- Water: Ad libitum
- Acclimation period: At least 4 days.
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12 h dark/ 12 h light cycle
IN-LIFE DATES: From: To:
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- physiological saline
- Details on dermal exposure:
- TEST SITE
- Area of exposure:
- % coverage:
- Type of wrap if used: The test material was applied to sleeves of rubber dental dam. each sleeve was wrapped around the trunk of the respective animal and secured with staples. An outer layer of gauze was wrapped around the trunk of each animal and secured with tape.
REMOVAL OF TEST SUBSTANCE
- Washing: Any unabsorbed test material remaining on the skin was removed by gentle sponging using a towel moistened with water.
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount applied: 5.0 g/kg
- Concentration: The test material was used as received and moistened with an appropriate volume of physiological saline prior to administration.
- Constant volume or concentration used: No data
- For solids, paste formed: Yes - Duration of exposure:
- 24 h
- Doses:
- 5 g/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: All animals were observed for signs of toxicity and behavioural change once a day with an additional check for viability during the day.
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs were noted once daily; body weight was measured on the day of dosing, on Day 7 and at the time of necropsy at the end of the 14-day observaiton period; skin reactions and other evidene of irritaiton or injury were noted once daily.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No deaths were noted during the observation period.
- Mortality:
- No deaths were noted during the observation period.
Any other information on results incl. tables
The acute dermal toxicity of XPI-187 Zinc Borate was evaluated in compliance with the conditions specified in the regulation for the enforcement of the Federal Insecticide, Fungicide and Rodenticide Act, the Toxic Substances Control Act and the OECD Guidelines
No deaths were noted during the observation period
The acute dermal LD50 value was found to be >5.0 g/kg in male and female New Zealand White rabbits
Body weight data
Animal number |
Sex |
Body weight (g) |
Body weight change (g) |
||
Day 0 |
Day 7 |
Day 14 |
Day 0 – 14 |
||
1-939 |
M |
2770 |
2945 |
3037 |
267 |
2-940 |
M |
3133 |
3289 |
3549 |
416 |
3-943 |
M |
2919 |
2868 |
3119 |
200 |
4-943 |
M |
3068 |
3112 |
3329 |
261 |
5-950 |
M |
2256 |
2436 |
2395 |
139 |
Mean |
|
2839 |
2930 |
3086 |
257 |
|
|
|
|
|
|
6-959 |
F |
2943 |
3208 |
3417 |
474 |
7-960 |
F |
3257 |
3208 |
3474 |
217 |
8-961 |
F |
3438 |
3249 |
3727 |
289 |
9-962 |
F |
2508 |
3601 |
2802 |
294 |
10-963 |
F |
3319 |
3519 |
3645 |
326 |
Mean |
|
3093 |
3231 |
3413 |
320 |
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The acute dermal toxicity of the test substance was evaluated in compliance with the conditions specified in the regulation for the enforcement of the Federal Insecticide, Fungicide and Rodenticide Act 940 CFR) the TSCA (40 CFR) and the OECD guidelines. No deaths were noted during the observation period. The acute dermal LD50 was found to be greater than 5.0 g/kg in male and female New Zealand White rabbits. The test material was classified as Toxicity Category IV (40 CFR 156) by dermal administration.
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