Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 214-254-7 | CAS number: 1117-86-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The water/octanol partition coefficient log Pow of 2.1, the moderately high water solubility of 7.5 g/L and the low molecular weight are favouring absorption of octane-1,2-diol. However, based on these properties bioaccumulation is rather unlikely
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
No specific study was performed on the absorption, distribution, metabolism and/or excretion (ADME) of octane-1,2-diol.
Absorption and systemic availability of octane-1,2-diol or metabolites after oral administration has been concluded from its moderately high water solubility (7.5 g/L at 20°C), partition coefficient (Log10Pow = 2.1), its relatively low molecular weight (146) and the finding of slightly reduced locomotor activity in rats treated in a 28-day oral (gavage) toxicity study at 1000 mg/kg bw/day. The three physicochemical properties also favour dermal uptake, although the systemic availability of octane-1,2-diol after dermal uptake is considered to be lower than after gastro-intestinal absorption.
The partition coefficient Pow and the moderately high water solubility of octane-1,2-diol favour absorption directly across the respiratory tract epithelium by passive diffusion. However, the risk of exposure by the inhalation route is considered to be low, because of its relatively low vapour pressure (0.28 Pa at 25°C, 0.15 Pa at 20°C).
All available experimental study results gave no indication regarding the metabolic pathway, distribution or excretion of octane-1,2-diol itself, but for the structural substance analogue, butane-1,2-diol (EC 209-527-2), excretion in the urine as its glucuronide or unchanged was demonstrated after i.v. infusion to the rabbit. Based on metabolism modelling on C6-, C8-, C10- and C12 alkane-1,2-diols С-oxidation, C-hydroxylation, glucuronidation and beta-oxidation were identified as possible pathways for forming corresponding metabolites, whereby hydroxylation and beta-oxidation are more likely to be favoured for the metabolic pathways of the latter two substance analogues.
Bioaccumulation was not investigated, but in view of its Log10Pow of 2.1, octane-1,2-diol is not considered to be bioaccumulative.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.