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Diss Factsheets
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EC number: 424-110-7 | CAS number: 194602-23-8 UK-143,108
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 August and 28 September 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: done under GLP and OECD method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 92/69/EEC, Method A8
- Principles of method if other than guideline:
- Test temperature: 20°c ± 0.5°C.
Test 1: aqueous stock solution (10 ml) and octanol saturated with water (50 ml) were combined in an 8 oz screw-capped glass jar and shaken mechanically for 15 minutes. The test was performed in duplicate.
Test 2: as for test 1 except that aqueous stock solution (20 ml) was used. Test 3: as for test 1 except that aqueous stock solution (40 ml) was used.
: 30 :
Blank test: as for test 2 except that water saturated with octanol was used in place of the aqueous stock solution. The blank was performed in duplicate. - GLP compliance:
- yes
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Test material form:
- solid: crystalline
- Details on test material:
- Identity: UK-143,108
Chemical name: 2-Ethoxy-5-(4-methyl-1- piperazinesulphonyl)benzoic acid
Expiry: 19 November 1995
Purity: 99.6% (excluding organic solvents)
Appearance: White to off white crystalline solid
Storage conditions: Dark at room temperature
Date received: 19 May 1995
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- -2.37
- Temp.:
- 20 °C
- Remarks on result:
- other: ± 0.1
- Details on results:
- The concentration of test substance in the aqueous stock solution was determined as 2950.0 /Lg/ml (mean of individual determinations 2986.0 and 2913.9 /Lg/ml).
Concentration of test substance based on mass of test substance used was 3034.0 /Lg/ml.
The aqueous phase concentrations ranged from 2651.8 - 3116.7 /Lg/ml with pH values of 5.45 - 5.75. The organic phase concentrations ranged from 10.100 - 13.209 J.Lg/ml.
Any other information on results incl. tables
Test |
Concentrationoftestsubstanceinorganicphase (µg/ml) |
Concentrationoftestsubstanceinaqueousphase(µg/ml) |
p |
MeanPforeach test |
MeanPforalldeterminations |
Logp |
|
||||||
lA1B
2A 2B
3A 3B |
10.100 11.968
12.324 12.749
13.209 12.932 |
2651.8 2786.2
3116.7 2876.5
2682.4 2994.8 |
0.0038087 0.0042955
0.0039542 0.0044321
0.0049243 0.0043182 |
0.0040521
0.0041932
0.0046213 |
0.0042888 |
-2.42 -2.37 |
-2.40 -2.35
-2.31 -2.36 |
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient (n-octanol/water) of UK-143,108 has been determined as:
Log P = -2.37 at 20°c
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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