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Diss Factsheets
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EC number: 219-460-0 | CAS number: 2439-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- BASF Test: Sprague-Dawley rats, 10 per sex per group, were exposed sequentially to the vapours of the test substance for 4 hours at dose levels of 1.08, 0.28, 0.17, 0.12, 0.11, and 0.09 mg/l (2x). The vapours were generated by feeding a metered amount of test substance into an evaporator heated to 60°C and were then mixed with supply air. After exposure a 14-day observation period followed.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-(dimethylamino)ethyl acrylate
- EC Number:
- 219-460-0
- EC Name:
- 2-(dimethylamino)ethyl acrylate
- Cas Number:
- 2439-35-2
- Molecular formula:
- C7H13NO2
- IUPAC Name:
- 2-(dimethylamino)ethyl prop-2-enoate
- Details on test material:
- - Name of test material (as cited in study report): Dimethylaminoethyl acrylate
- Physical state: clear liquid
- Analytical purity: > 90 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: MUS RATTUS, Brunnthal, FRG
- Weight at study initiation: 185 ± 15 g
- Diet: Herilan MRH (H . EGGERSMANN KG, Rinteln/Weser, FRG) ad libitum
- Water: Tap water ad libitum
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Wire mesh cages with 5 animals per cage were transfered to the whole-body exposure chamber made of glass and steel.
- Exposure chamber volume: 200 l
- Pressure in air chamber: negative pressure of 10 Pa
- Atmosphere generation: The vapours were generated by feeding a metered amount of test substance into an evaporator heated to 60°C and were then mixed with supply air.
TEST ATMOSPHERE
- Brief description of analytical method used: gas chromatograph (HP 5840 A)
- Samples taken from breathing zone: yes - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Group 1: 1.08 mg/l; Group 2: 0.28 mg/l; Group 3: 0.17 mg/l; Group 4: 0.12 mg/l; Group 5: 0.11 mg/l; Group 6: 0.09 mg/l; Group 7: 0.09 mg/l
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: A check for dead or moribund animals and clinical symptoms was made daily. Bodyweights were determined before exposure, 7 days after exposure and at the and of the study.
- Necropsy of survivors performed: yes - Statistics:
- Statistical analysis was performed according to Finney (Probitanalysis 1971, p. 1 - 150).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 0.09 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 0.22 mg/L air (analytical)
- Based on:
- test mat.
- 95% CL:
- 0.19 - 0.29
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 0.18 mg/L air (analytical)
- Based on:
- test mat.
- 95% CL:
- 0.15 - 0.25
- Exp. duration:
- 4 h
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 0.27 mg/L air (analytical)
- Based on:
- test mat.
- 95% CL:
- 0.21 - 0.56
- Exp. duration:
- 4 h
- Mortality:
- Animals died up to 5 days after exposure. Surviving animals of group 2 still showed symptoms after 14 days. The surviving animals of the other groups recovered after 5-7 days and showed no abnormal symptoms any more.
- Clinical signs:
- other: Group 1 to 3 showed aqueous to red nose and eye discharge, eyelid closure, dyspnoea, apathy, reduced pain reaction (1), cornea opacity (1,2), scrubby and clotted coat, lurching and high stepping gait, flatulence and abdominal position (1). Group 4 to 7 s
- Body weight:
- Female animals of group 2 and 4 and male animals of group 2 showed reduced body weight gain. Male animals of group 3, 4 and 5 showed reduced body weight gain after 7 days, which normalised after 14 days.
- Gross pathology:
- Animals that died: Heart: acute dilatation right, acute congested hyperemia; Lung: acute pulmonary emphysema, hyperemia with edema; Liver: sporadic marginally dilated periphery of lobules.
Sacrificed animals: Nothing abnormal detected.
Any other information on results incl. tables
Exposure levels and mortality:
Group |
Analytical Concentration (mg/l) |
Mortality (dead rats/exposed rats) |
||
Male |
Female |
Total |
||
1 |
1.08 |
10/10 |
10/10 |
20/20 |
2 |
0.28 |
8/10 |
5/10 |
13/20 |
3 |
0.17 |
4/10 |
2/10 |
6/20 |
4 |
0.12 |
2/10 |
0/10 |
2/20 |
5 |
0.11 |
5/10 |
0/10 |
5/20 |
6 |
0.09 |
0/10 |
0/10 |
0/20 |
7 |
0.09 |
0/10 |
0/10 |
0/20 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.