Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-220-5 | CAS number: 3033-62-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Animal studies indicate the test substance is rapidly absorbed following dermal, i.v. or inhalation exposure, and eliminated, unchanged, primarily in the urine. Based on the i.v. studies, the elimination half-life for the test substance is ~14 - 18 hours in rats (2 mg/kg and 200 mg/kg administered dose, respectively) and ~26 - 40 hours in the rabbit (1 mg/kg and 100 mg/kg administered dose, respectively).
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - dermal (%):
- 64.5
- Absorption rate - inhalation (%):
- 60
Additional information
In a vapour inhalation toxicokinetics study in Fischer 344/NHsd rats, the test substance was readily absorbed at a constant rate during exposure and was largely eliminated by urinary excretion following exposure, without significant accumulation in any specific organ. Evaluation of the disposition of the test substance showed that the majority of radioactivity (58% of the recovered dose) was found in the urine. Approximately 3% of the recovered dose was present in the feces and less than 1% of the recovered dose was present in the organs and tissues saved at necropsy; however, 29% was present in the carcass.
In a dermal and intravenous toxicokinetics study in CDF Fischer 344 rats, the pharmacokinetic profile was consistent with a two-compartment open model in which elimination is primarily by urine excretion of the unchanged test material. Metabolism was not a major feature of the test substance elimination.
The majority of the radioactivity administered at both intravenous dose levels was eliminated in the urine (high dose: 64.4%; low dose: 60.8%); less than 5% recovery in the feces (high dose: 5.6%; low dose: 4.0%), with total percent dose recovered reported as 75% in the high dose and 69.5% in the low dose. No urinary metabolites were detected in the urine, indicating the test substance is largely eliminated unchanged in the urine.
Following dermal exposure to a 200 mg/kg dose of the test substance, the major fraction of the excreted dose was found in the urine, accounting for 24% of the dose (approximately 95% of the excreted dose). Approximately 1 to 2% of the dose (ca. 5% of the excreted dose) was recovered in the feces of male and female rats. The cutaneous bioavailability of the test substance was calculated to be 78.2% in males and 50.8% in females (calculated as % Bioavailability = [(AUC8) cutaneous ÷ (AUC8) intravenous] x 100), thus the absorption rate constant was significantly greater for males than for females. There was no remarkable tissue specific accumulation in male or female rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.