Registration Dossier
Registration Dossier
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EC number: 918-594-3 | CAS number: 7723-14-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
A bacterial reverse mutation assay (Ames test) has been performed on Red Phosphorus covering the strains Salmonella typhimurium TA98, TA100, TA1535, TA1537, and E. coli WP2 uvr A. There was no increase in the number of revertant colonies with any of the tester strains.
Red Phosphorus also yielded negative results in anin vitrogene mutation study in mammalian cells (HPRT test) in concentration up to 100 µg/ml in the presence and 40 µg/mL in the absence of metabolic activation.
Red Phosphorus was assessed for its potential to induce chromosomal aberrations in V79 cells in vitro. The test item did not induce chromosome aberrations. Therefore, Red Phosphorus is considered to be non-mutagenic in this in vitro chromosome aberration test when tested up to the highest evaluable concentration (78.1 µg/mL).
Short description of key information:
- Ames test: negative
- Gene mutation assay in V79 cells: negative
- in vitro Chromosome Aberration test in V79 cells: negative
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
It can be concluded from the data available that mutagenicity and genotoxicity are not caused by Red Phosphorus and therefore classification for this end point is not warranted.
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