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EC number: 200-824-2 | CAS number: 74-95-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted prior to availability of the appropriate OECD and OPPTS testing guidelines. However, the study was well documented and is scientifically acceptable. Hence, it was identified as a key study and was graded klimisch 2.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Rabbits were inoculated with DBM in the eye. Examinations for signs of irritation or injury were made at intervals of 1, 2, 4, 8, 24, 48 and 72 hours after the rabbits were exposed to the test material. Scoring was performed according to Draize procedure.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dibromomethane
- EC Number:
- 200-824-2
- EC Name:
- Dibromomethane
- Cas Number:
- 74-95-3
- Molecular formula:
- CH2Br2
- IUPAC Name:
- dibromomethane
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- No further information
Test system
- Controls:
- other: The contralateral eye served as control.
- Amount / concentration applied:
- 0.1 ml (3 drops) of the test material (unspecified purity, DBM) in the eye.
- Observation period (in vivo):
- Examinations for signs of irritation or injury were made at intervals of 1, 2, 4, 8, 24, 48 and 72 hours after the rabbits were exposed to the test material.
- Number of animals or in vitro replicates:
- Six New Zealand White (NZW) rabbits
- Details on study design:
- Six New Zealand White (NZW) rabbits were inoculated with 0.1 ml (3 drops) of the test material (unspecified purity, DBM) in the eye. The tested rabbits were free of any pre-test ocular abnormalities. The contralateral eye served as control. Examinations for signs of irritation or injury were made at intervals of 1, 2, 4, 8, 24, 48 and 72 hours after the rabbits were exposed to the test material. Scoring was performed according to Draize procedure.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 hours
- Remarks on result:
- other: moderate eye irritation
- Irritant / corrosive response data:
- Immediately following the introduction of DBM into the conjunctive sac, the eye closed and the rabbit rubbed the eye with a foot. After several minutes the rubbing stopped. Within 8 hours a capillary congestion and edema of the third eyelid developed.
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information
- Conclusions:
- DBM caused moderate eye irritation which lasted 3 days or more following inoculation.
- Executive summary:
Six New Zealand White (NZW) rabbits were inoculated with 0.1 ml (3 drops) of the test material (unspecified purity, DBM) in the eye. The tested rabbits were free of any pre-test ocular abnormalities. The contralateral eye served as control. Examinations for signs of irritation or injury were made at intervals of 1, 2, 4, 8, 24, 48 and 72 hours after the rabbits were exposed to the test material. Scoring was performed according to Draize procedure.
Immediately following the introduction of DBM into the conjunctive sac, the eye closed and the rabbit rubbed the eye with a foot. After several minutes the rubbing stopped. Within 8 hours a capillary congestion and edema of the third eyelid developed. DBM caused moderate eye irritation which lasted 3 days or more following inoculation.
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