Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 234-426-5 | CAS number: 12003-38-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was cited in a reliable CIR monograph on the toxicity of Fluorphlogopite. No further information was provided.
Data source
Reference
- Reference Type:
- publication
- Title:
- Final Report on the Safety Assessment of Synthetic Fluorphlogopite as Used in Cosmetics
- Author:
- Becker, L.C.
- Year:
- 2 012
- Bibliographic source:
- Cosmetic Ingredient Review
Materials and methods
Test guideline
- Deviations:
- not applicable
- Remarks:
- - no information available
- Principles of method if other than guideline:
- Information on the guideline followed are not available.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- synthetic fluorphlogopite
- IUPAC Name:
- synthetic fluorphlogopite
- Details on test material:
- no details provided.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- No information available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on study design:
- No information available
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 9 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality reported
- Clinical signs:
- other: no adverse clinical signs
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of a published acute oral toxicity study in rats, the LD50 of Fluorphlogopite was > 9000 mg/kg bw.
- Executive summary:
The acute oral toxicity of synthetic Fluorphlogopite was investigated in female Sprague-Dawley rats. The LD50 value was > 9000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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