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EC number: 210-036-0 | CAS number: 603-35-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May - September 1951
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Screening test; discrepancy between documented test parameters and standard methods, but scientifically acceptable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 952
- Report date:
- 1952
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF-internal standard method, conducted before OECD 423 was in place
- Principle of test: The acute oral toxicity to rats was evaluated by a single administration of 10% oily suspension, equivalent to doses of 250, 500, 1000 and 2000 mg/kg test material. Afterwards, the animals were observed 8 days for mortality and syptoms of acute intoxication. Dead animals, time to death and symptoms of acute intoxication were recorded. The mean lethal dose was determined. - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Triphenylphosphine
- EC Number:
- 210-036-0
- EC Name:
- Triphenylphosphine
- Cas Number:
- 603-35-0
- Molecular formula:
- C18H15P
- IUPAC Name:
- triphenylphosphine
- Test material form:
- solid: crystalline
Constituent 1
- Specific details on test material used for the study:
- TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final dilution of a suspended solid: 10 %
FORM AS APPLIED IN THE TEST (if different from that of starting material): oily suspension
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10% - Doses:
- 250, 500, 1000, 2000 mg/kg bw
- No. of animals per sex per dose:
- - sex unspecified, 5-10 animals per dose group
- 250 mg/kg: 5 animals
- 500 mg/kg: 10 animals
- 1000 mg/kg: 10 animals
- 2000 mg/kg: 5 animals - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 8 days
- Frequency of observations: daily
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 700 mg/kg bw
- Remarks on result:
- other: 1/10 dead at 500 mg/kg; 10/10 dead at 1000 mg/kg
- Mortality:
- No mortality at 250 mg/kg bw, but 1/10 at 500 mg/kg and 100% at doses > 1000 mg/kg. Death occured within 1 - 4 days after application.
- Clinical signs:
- other: Animals that died showed apathy, impaired balance and inappetence. No clinical findings in all surviving animals.
Any other information on results incl. tables
Table 1: Mortality
Dose [mg/kg] |
Number of animals |
Dead animals |
Time to death [days] |
2000 | 5 | 5/5 | 2-3 |
1000 | 10 | 10/10 | 1-4 |
500 | 10 | 1/10 | 2 |
250 | 10 | 0/5 | - |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 = 700 mg/kg
- Executive summary:
The acute oral toxicity to rats was evaluated according to a BASF-internal standard method. Therefore, a single administration of 10% oily suspension, equivalent to doses of 250, 500, 1000 and 2000 mg/kg test material was undertaken. Afterwards, the animals were observed 8 days for mortality and poisoning syptoms. No mortality at 250 mg/kg bw, but 1/10 at 500 mg/kg and 100% at doses > 1000 mg/kg. Death occurred within 1 - 4 days after exposure. Animals that died showed apathy, impaired balance and inappetence. Surviving animals showed no clinical findings. The mean lethal dose was determined to be 700 mg/kg.
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