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EC number: 232-055-3 | CAS number: 7784-25-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity: Oral: LD50 females: > 2000 mg/kg bw (K, Reliability 1)
Acute toxicity: Dermal: LD50 combined: > 2000 mg/kg bw (K, Reliability 1)
Acute toxicity: Inhalation: exposure based waiving
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Oral route:
In an acute toxic class method study, Aluminium ammonium sulfate was administered by gavage to 6 female Wistar rats at a single dose of 2000 mg/kg bw. This study was performed in compliance with Good Laboratory Practices and according to OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method).
At the dose level of 2000 mg Aluminium ammonium sulfate / kg bw, all animals were found normal after dosing and during the observation period. There was a normal increase in the body weight of all treated animals and no mortality was observed. The gross pathological examination revealed no anormality due to the test substance. Therefore, the acute oral lethal dose (LD50) of Aluminium ammonium sulfate is > 2000 mg / kg bw .
Under the test conditions, Aluminium ammonium sulfate is not classified according to the criteria of the Annex VI to the CLP Regulation and to the 67/548/EC Directive.
Inhalation:
According to the REACH requirements, the
acute toxicity by inhalation (required in section 8.5.2) does not need
to be conducted since the acute toxicity study is still available by
both the oral and the dermal route. However, regarding the aluminium
ammonium (bis)sulfate physical state as an inhalable fraction containing
powder, human exposure by inhalation should be considered even if the
vapour pressure is low.
The granulometry of aluminium ammonium (bis)sulfate showed no detectable
particles in the respirable fraction (< 10 µm) and less than 10% of
total particles in the inhalable fraction (< 100 µm). These particles
are expected to be dissolved by the mucus from the respiratory tract in
order to be ingested. Consequently the acute toxicity by inhalation is
warranted due to the potential for acute oral toxicity. However, as no
systemic effects are observed during the acute oral testing, no systemic
toxicity is expected to occur after inhalation of aluminium ammonium
(bis)sulfate. Moreover, no local effects are observed during the acute
dermal testing, nor in skin and eye irritation studies. Therefore, local
toxicity is not expected after aluminium ammonium (bis)sulfate exposure
by inhalation.
Finally, no toxicity is expected after exposure of aluminium ammonium
(bis)sulfate by inhalation.
Dermal route:
In an acute dermal toxicity study, Aluminium ammonium sulfate was applied by dermal way to 10 males and females Wistar rats at dose levels of 0 (negative control) and 2000 mg/kg bw. This study was performed in compliance with Good Laboratory Practices and according to OECD Guideline 402 (Acute Dermal Toxicity).
No clinical signs, no significant changes in the body weight and no mortality were observed in the treated group (2000 mg / kg bw) in comparison with the control group. The external and internal examinations revealed no abnormality due to the test substance. The acute dermal lethal dose (LD50) of Aluminium ammonium sulfate in rats is higher than 2000 mg / kg bw.
Under the test conditions, Aluminium ammonium sulfate is not classified according to criteria of the Annex VI to the CLP Regulation and to the Directive 67/548/EEC.
Justification for classification or non-classification
Harmonized classification:
No harmonized classification is available.
Self classification:
Oral route:
Based on the available data, aluminium ammonium (bis)sulfate is not classified for acute oral toxicity according to the CLP Regulation and according to the criteria of the annex VI to the Directive 67/548/EC as the LD50 is higher than 2000 mg/kg bw.
Inhalation route:
According to the exposure based waiving taking into account both the available granulometry data on the powder and the absence of systemic effects expected during the acute exposure by inhalation (see § 7.2.2), Aluminium ammonium (bis)sulfate is not classified for acute toxicity by inhalation according to the CLP regulation and according to the criteria of the annex VI to the Directive 67/548/EEC.
Dermal route:
Based on the available data, aluminium ammonium (bis)sulfate is not classified for acute dermal toxicity according to the CLP Regulation and according to the criteria of the annex VI to the Directive 67/548/EC as the LD50 is higher than 2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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