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Diss Factsheets
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EC number: 200-652-8 | CAS number: 67-43-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
When rainbow trout (O. mykiss) were exposed to pentapotassium salt of DTPA, the 96-hour LC50 was > 1,000 mg/L. Stoichiometric conversion from the pentapotassium salt to the free acid resulted in a 96-hour LC50 value of 674 mg/L for DTPA (free acid). However the supporting study provides a measured media effect value (although nominal)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 674 mg/L
Additional information
Two acute freshwater fish studies were assessed for this endpoint. One study was conducted with rainbow trout (Oncorhynchus mykiss) exposed to the pentapotassium salt of DTPA, while the other study was conducted with bluegill sunfish (Lepomis machrochirus) exposed to the pentasodium salt of DTPA. Upon contact with water, these DTPA salts are expected to dissociate, thus, these test chemicals are considered essentially equivalent to the free acid form of DTPA. Both studies were found to be of good quality and were comparable to or equivalent to guideline studies. The acute test with the rainbow trout was a limit test that concluded that the 96 hour LC50 for DTPA (pentapotassium salt) was >1,000 mg/L, which was equivalent to 674 mg/L DTPA (free acid). The acute test with the bluegill sunfish concluded that the 96 -hour LC50 for DTPA (pentasodium salt) was 1115 mg/L, equivelent to 880 mg/L DTPA (free acid). Since these toxicity results were conducted with two different fish species, the lower of the two values (674 mg/L) was selected as the key parameter for this endpoint.
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