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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Experimental data for the substantiation of the maximum allowable concentration of test chemical in the air of work areas
Author:
Markarian KL, Babaian EA.
Year:
1988
Bibliographic source:
Gig Tr Prof Zabol. 1988 Jan;(1):49-50.
Reference Type:
review article or handbook
Title:
DPIM: ALS990
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials); Gigiena Truda i Professional'nye Zabolevaniia. Labor Hygiene and Occupational Diseases. 32(1) (1988), 49.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute inhalation toxicity of test chemical in rats.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-aminophenol
EC Number:
209-711-2
EC Name:
3-aminophenol
Cas Number:
591-27-5
Molecular formula:
C6H7NO
IUPAC Name:
3-aminophenol
Details on test material:
Name of test material: 3-aminophenol
Substance type: Organic
Physical state: Solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remark on MMAD/GSD:
not specified
Details on inhalation exposure:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Remarks on duration:
Exposure duration not reported
Concentrations:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
1 162 mg/m³ air
Based on:
test mat.
Remarks on result:
other: Other details not available
Mortality:
50% mortality observed
Clinical signs:
other: Peripheral nerve and sensation: spastic paralysis with or without sensory change Behavioural: excitement
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
Acute inhalative toxicity value (LC50) of test chemical to rat was found to be 1162 mg/m³.
Executive summary:

The acute inhalation toxicity test was conducted on rats. Test animals were observed for body weight change and mortality.Clinical signs like Peripheral nerve and sensation: spastic paralysis with or without sensory change and Behavioural excitement was observed.

Hence, Acute inhalative toxicity value (LC50) of test chemical to rat was found to be 1162 mg/m³.This chemical has harmonised classification in the inhalation toxicity category IV.