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EC number: 232-164-6 | CAS number: 7789-41-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Semichronic Toxicity Study of Sodium Bromide in Rats
- Author:
- Van Logten M.J., Wolthius M., Rauws A.G., Kroes R., Den Tonkelaar E.M., Berkvens H. and van Esch G.J.
- Year:
- 1 974
- Bibliographic source:
- Toxicology, 2 (1974), 257-267
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No guidelines available at that time
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium bromide
- EC Number:
- 231-599-9
- EC Name:
- Sodium bromide
- Cas Number:
- 7647-15-6
- IUPAC Name:
- sodium bromide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar SPF
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- 90 days
- Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 75, 300, 1200, 4800 or 19200 ppm
Basis:
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Post-exposure period: None
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 300 ppm
- Based on:
- other: equivalent to 15 mg Br/kg bw/day
- Sex:
- male/female
- Dose descriptor:
- LOAEL
- Effect level:
- 1 200 ppm
- Based on:
- other: equivalent to 62 mg Br/kg bw/day
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The test substance was administered in the diet for 90 days to 5 groups of rats (10 rats per sex per dose group) at levels of 0, 75, 300, 1200, 4800 or 19200 ppm. Clinical toxicological signs and body weights were noted weekly and haematological, clinical chemistry and urinalysis measurements were made between weeks 10 and 13 of the 90 day period. Complete necropsies were performed on surviving animals at study end. Histopathological examinations were performed on the major organs/tissues.
Animals in the 19200 ppm dose group did not groom themselves sufficiently and exhibited signs of motor incoordination. The male animals in this group showed significant growth retardation. Plasma bromide levels increased within 3 weeks to a plateau. In all groups, except in the highest dosage group, these plateaus were directly proportional to the bromide concentrations in the diets, as were the bromide concentrations in the brain and kidneys after 90 days. Total molar halogen concentration in plasma, however, remained constant throughout the investigation. No striking effects on haematological and biochemical parameters were seen except for a doubling of the percentage of neutrophil granulocytes in the highest dosage group. In female animals on 1200, 4800 and 19200 ppm and in male animals on 19200 ppm bromide an increase of relative thyroid weight was found. In male rats an increase of the relative weight of the adrenals was found in the 19200 ppm group and a decrease of relative prostate weight was seen in the two highest dosage groups. Histopathologically a dose-related disturbance of the endocrine system and some of its target organs was found. One animal was sacrificed prior to the end of the 90 days for humane reasons. No other mortality occurred.
1.1.1 LO(A)EL
1200 ppm (equivalent to a minimum of 62 mg (Br-)/kg bw/day)) (increased relative thyroid weight)
1.1.2 NO(A)EL
300 ppm (equivalent to a minimum of 15 mg (Br-)/kg bw/day))
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