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EC number: 272-805-7 | CAS number: 68912-13-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 February 1980 - 27 February 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test was conducted according to methods similar to OECD guideline 401 (limit test) and was performed pre-GLP. A concise description of the protocol is available and results are reported clearly.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- pre-GLP test
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl propionate
- EC Number:
- 272-805-7
- EC Name:
- 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl propionate
- Cas Number:
- 68912-13-0
- Molecular formula:
- C13H18O2
- IUPAC Name:
- Reaction mass of 3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-5-yl propionate and 3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-6-yl propionate
- Test material form:
- liquid
1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace animals
- Age at study initiation: approximately 8 weeks old
- Weight at study initiation: 179 - 298 grams
- Fasting period before study: 16 - 20 hours
- Housing: 5 animals per cage in suspended wire mesh cages (20 x 10 x 7)
- Diet: Fresh Purina rat chow ad libitum
- Water: ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 21 C
- Animal room was reserved exclusively for rodents on acute tests and kept clean.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 5.0 g/kg (5000 mg/kg) (The dose was based on the sample weight as calculated from the specific gravity)
- Doses:
- 5000 mg/kg body weight
- No. of animals per sex per dose:
- 10 male rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: rats were observed 3 - 4 hours after dosing and once daily for 14 days
- Necropsy of survivors performed: yes, all animals were sacrified and examined for gross pathology
- Other examinations performed: mortality, toxicity and pharmacological effects - Statistics:
- The LD50 was calculated according to the method of Litchfield, JT Jr & Wilcoxon, F. JPET 96:99, 1949 (if possible).
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed (0/10)
- Clinical signs:
- other: All animals had lethargy and piloerection 3 - 4 hours post dosing. Lethargy persisted in all animals to day 1. One instance of oily anogenital area was noted on day 1. Chromorhinorrhea was noted in five or more animals on day 2 and 3. All animals were nor
- Gross pathology:
- On day 14, internal organs of all animals were normal upon superficial examination.
Applicant's summary and conclusion
- Interpretation of results:
- other: not acute harmful
- Remarks:
- according to EU CLP (EC 1272/2008 and its amendments)
- Conclusions:
- In an acute oral toxicity study with Cyclaprop, all animals survived a dose of 5000 mg/kg bw. It can be concluded that Cyclaprop was not acute toxic by the oral route under the conditions of this test.
- Executive summary:
The acute oral toxicity of Cyclaprop was determined in an acute oral toxicity study according to methods similar to OECD401 (limit test). Ten male rats were dosed 5000 mg/kg bw test material by gavage. The rats were observed 3 - 4 hours after dosing and once daily for 14 days. Mortality, toxicity, pharmacological effects and gross pathology were examined.
All animals survived a dose level of 5000 mg/kg bw, resulting in a LD50 > 5000 mg/kg bw. The most prevalent toxic signs were lethargy (persisting to day 1 in all animals), piloerection (3 -4 hrs post-dosing in all animals) and chromorhinorrhea (on day 2 and 3 in five or more animals).All animals were normal on day 4 until day 12. Isolated instances of ptosis, chromorhinorrhea, diarrhea, piloerection and lethargy were noted on day 13 and 14. Nine animals were normal on day 14. After necropsy on day 14, internal organs of all animals normal upon superficial examination.
Based on these results, Cyclaprop does not need to be classified as acute toxic via the oral route in accordance with the criteria outlined in Annex VI of 67/548/EEC and Annex I of 1272/2008/EC, under the conditions of this test.
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