Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-453-4 | CAS number: 107-02-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1979-05-09 to 1979-06-11
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Type of study / information:
- inhalation toxicity, sensory (upper airway) irritation potential
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Measurement of mouse response to a sensory irritant, which is a reflex respiration rate decrease induced by trigeminal nerve stimutalion and phrenic nerve inhibition of respiration. The extent of respiration rate slowing is dose related. An RD50 (concentration of material required to produce a 50% respiration rate decrease) can be determined for sensory irritants by linear regression. Method according to Alarie 1973 and Kane, Barrow and Alarie (1979)
- GLP compliance:
- no
Test material
- Reference substance name:
- Acrylaldehyde
- EC Number:
- 203-453-4
- EC Name:
- Acrylaldehyde
- Cas Number:
- 107-02-8
- Molecular formula:
- C3H4O
- IUPAC Name:
- acrylaldehyde
- Details on test material:
- - Name of test material (as cited in study report): Acrolein (CH2=CHCHO, Acrylaldehyde, Propenal, acrylic aldehyde)
no further data given
Acrolein was tested amoung other substances
Constituent 1
Results and discussion
Any other information on results incl. tables
Maximum responses occured after ten minutes of exposure to the test material. The dose response curve was linear for concentrations below 2 ppm and the linear regression was calculated from these points. The RD50 for acrolein is 1.27 ppm (R=0.89, C.I. 1.07 to 1.52 ppm. The authors compared this results with results reported by Alarie. The RD50 values were quite similar (value reported by Alarie= 1.68 ppm). Haskell´s data agreed with Alarie´s data not only quantitatively, but also in the typ of response. Both groups found acrolein produces a uniform response over the ten minute exposure period.
Applicant's summary and conclusion
- Executive summary:
In an Alarie test, which is an acute inhalation toxicity study designed to measure the mouse response to a sensory irritant, groups of 4 male Swiss mice were exposed head-only to acrolein (no information on a.i.). Exposure duration was 10 minutes and acrolein. Concentrations from 0.8.7 ppm were tested. The extent of dose related respiration rate slowing was determined and the RD50 (concentration of material required to produce a 50% respiration rate decrease) calculated.
Acrolein is a sensory irritant.
RD50 Males = 1,27 ppm (R=0.89; 95% CI 1.07 - 1.52 ppm)
The dose response curve was linear for concentrations below 2 ppm. Maximum responses occures after 10 minutes of exposure to the test material.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.