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EC number: 231-626-4 | CAS number: 7659-86-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
EHTG was found to be slightly irritating to skin and no ocular reactions were observed in rabbits.
Skin Irritation
A single dose of 0.5 mL undiluted EHTG was applied to the skin of 3 male New Zealand White rabbits under a semi-occlusive dressing for four hours (Clouzeau, 1993) following OECD test guideline 404. Skin reactions were observed approximately 1 hour, 24, 48 and 72 hours after removal of the dressing and then daily until 8 days in order to observed their reversibility. The mean values of the scores for erythema and oedema were calculated for each animal. The mean scores over 24, 48 and 72 hours for individual animals were 1.3, 1.7, and 1.3 for erythema and 0.0, 0.0, and 0.3 for edema. No ulceration of necrosis was noted. Erythema and edema had reversed by day 6 and by day 3, respectively. EHTG was slightly irritating under the conditions of this test.
Eye irritation
0.1 mL undiluted EHTG was instilled into the conjunctival sac of the left eye of 3 male rabbits (Clouzeau, 1993) following OECD test guideline 405. The right eye was not treated and served as control. The eyes were not rinsed after administration of the test item. Ocular reactions were observed approximately 1 hour, 24, 48 and 72 hours after the administration. No ocular reactions were observed during the study; EHTG was not irritating to the rabbit eye under the conditions of this study.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 7 to 21 September 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- Study conducted prior to the adoption of the most recent version of this Guideline
- Deviations:
- yes
- Remarks:
- The results of clinical examination were not reported; the age of animals was not indicated; the temperature limits were below the recomended ones.
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage cunicole de Val de Selle, France
- Age at study initiation: not reported
- Weight on the day of treatment: mean: 2.9 +/- 0.3 kg
- Housing: individually in polystyrene cages (35 x 55 x 32 cm or 48.2 x 55 x 36.5 cm)
- Diet (e.g. ad libitum): 112 C pelleted diet
- Water (e.g. ad libitum): filtered by a Millipore membrane
- Acclimation period: at least 5 days before the beginning of the study
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 +/- 3
- Humidity (%): 50 +/- 20
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 7 september 1993 To: 21 September 1993 - Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped using electric clippers
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- 8 days following exposure
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm2 gauze patch
- Type of wrap if used: restraining bandage
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 4 hours
SCORING SYSTEM: Erythema and oedema were noted from 0 (no observation) to 4 (severe observation) - Irritation parameter:
- erythema score
- Basis:
- other: animals #1 and 3
- Time point:
- other: 24 + 78 + 72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24 + 48 + 72 h
- Score:
- 1.66
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24 + 48 + 72 h
- Score:
- 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 2 days
- Irritation parameter:
- edema score
- Basis:
- other: animals #2 and 3
- Time point:
- other: 24 + 48 + 72 h
- Score:
- 0
- Max. score:
- 4
- Other effects:
- Results for mortality and behaviour were not reported.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance was found to be slightly irritating to rabbits skin with some erythema observed and scored 2. No more erythema were observed at day 6 post-treatment. Only slight oedema (score 1) was observed in one animal at 24 h following application.
- Executive summary:
A single dose of 0.5 mL undiluted EHTG was applied to the skin of 3 male New Zealand White rabbits under a semi-occlusive dressing for four hours following OECD test guideline 404. Skin reactions were observed approximately 1 hour, 24, 48 and 72 hours after removal of the dressing and then daily until 8 days in order to observed their reversibility. The mean values of the scores for erythema and oedema were calculated for each animal. The mean scores over 24, 48 and 72 hours for individual animals were 1.3, 1.7, and 1.3 for erythema and 0.0, 0.0, and 0.3 for edema. No ulceration of necrosis was noted. Erythema and edema had reversed by day 6 and by day 3, respectively. EHTG was slightly irritating under the conditions of this test.
Reference
Moderate cutaneous reactions were observed for up to 48 hours after removal of the dressing. They consisted of erythema (scores of 1 and 2) and oedema (score of 1) in 3 animals. Erythema and oedema had reversed by day 6 and 3, respectively.
By day 4, a dryness of the skin was observed at the treatment site. No ulceration or necrosis was observed.
Table 1 Individual skin irritation scores according to the Draize scheme
Erythema |
Oedema |
|||||
Animal No |
1 |
2 |
3 |
1 |
2 |
3 |
After |
1 |
2 |
1 |
0 |
0 |
0 |
After 24 h |
2 |
2 |
2 |
1 |
0 |
0 |
After 48 h |
1 |
2 |
1 |
0 |
0 |
0 |
After 72 h |
1 |
1 |
1 |
0 |
0 |
0 |
Mean score 24-72 h |
1.44 |
0.11 |
||||
Day 5 |
1 |
1 |
1 |
0 |
0 |
0 |
Day 6 |
0 |
0 |
0 |
0 |
0 |
0 |
Day 7 |
0 |
0 |
0 |
0 |
0 |
0 |
Day 8 |
- |
0 |
0 |
- |
0 |
0 |
- cutaneous examination not performed
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 21 to 24 September 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- Study conducted prior to the adoption of the most recent version of this Guideline
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Elevage cunicole de Val de Selle, France
- Sex: male
- Age at study initiation: not reported
- Weight on the day of treatment: 3.1 +/- 0.5 kg
- Housing: individually in polystyrene cages (35 x 55 x 32 or 48.2 x 58 x 36.5 cm)
- Diet: 112 C pelleted diet ad libitum
- Water: filtered by Millipore membrane ad libitum
- Acclimation period: at least 5 days before the beginning of the study
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 +/- 3
- Humidity (%): 50 +/- 20
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 21 September 1993 To: 24 September 1993 - Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL was instilled into the conjunctival sac of the left eye of rabbits - Duration of treatment / exposure:
- The eyes were not rinsed after administration of the test substance
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: no
SCORING SYSTEM: treated eyes were scored for conjunctival lesions and discharge, iris lesions and corneal lesions. - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 +48 + 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24 +48 + 72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 +48 + 72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 +48 + 72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- No ocular reactions were observed during the study.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 2-ethylhexyl mercaptoacetate is not irritating to eyes.
- Executive summary:
0.1 mL undiluted EHTG was instilled into the conjunctival sac of the left eye of 3 male rabbits following OECD test guideline 405. The right eye was not treated and served as control. The eyes were not rinsed after administration of the test item. Ocular reactions were observed approximately 1 hour, 24, 48 and 72 hours after the administration. No ocular reactions were observed during the study; EHTG was not irritating to the rabbit eye under the conditions of this study.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Justification for classification or non-classification
According to REGULATION (EC) No 1272/2008 of 16 December 2008 and the available skin and eye irritation data, 2 -ethylhexyl mercaptoacetate should not be classified as irritating to skin or eyes.
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