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EC number: 202-879-8 | CAS number: 100-69-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: OECD 408
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: While this study is not a reproductive toxicity screening study, observations of the reproductive organs in subchronic studies can be helpful in understanding target organ toxicity.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 408: 90-day repeated dose oral toxicity
- Deviations:
- yes
- Remarks:
- 5 days/week rather than 7 days/week. This study precedes establishment of 408 Guideline
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- no
Test material
- Reference substance name:
- 2-vinylpyridine
- EC Number:
- 202-879-8
- EC Name:
- 2-vinylpyridine
- Cas Number:
- 100-69-6
- Molecular formula:
- C7H7N
- IUPAC Name:
- 2-ethenylpyridine
- Details on test material:
- The material submitted had a 97% minimum purity, with inhibitor (tertiary butyl catechol) added 0.09-0.11% by weight. Material was distilled byt he Chemical Processing Engineering Laboratory, of Kodak Research Laboratories to remove impurities and stabilizer. Average purity of triplicate analysis was 97.34 ± 0.15% pure 2-VP.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- The concentration of the test material in corn oil was assayed (UV/Vis spectroscopy) throughout the experimental period. 2-Vinylpyridine was determined to be stable for at least 11 days, as prepared and stored.
- Duration of treatment / exposure:
- 92 days, 5 days per week excluding weekends.
- Frequency of treatment:
- 5 days per week excluding weekends.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 20, 60, 120 mg/kg body weight/day
Basis:
actual ingested
- No. of animals per sex per dose:
- 30
- Positive control:
- none
Examinations
- Parental animals: Observations and examinations:
- Adult males and non-gravid females were examined for gross abnormalities and for histopathologic effects of treatment.
- Postmortem examinations (parental animals):
- Body weight, organ weights, gross and histopathological examination of organs.
- Statistics:
- All numerical data were evaluated using computerized tests as follows: One-way analysis of variance, Bartlett's test and Duncan's multiple range test. F-tests were performed where the Bartlett's test indicated a significant difference in variances which would interfere with interpretation of analytical results.
- Reproductive indices:
- Organ weight and histopathologic examination
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- effects observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- Food consumption and body weight gain was significantly decreased at 120 mg/kg bw/d.
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Description (incidence and severity):
- Food consumption and body weight gain was significantly decreased at 120 mg/kg bw/d.
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- no effects observed
- Description (incidence and severity):
- No histopathology
Details on results (P0)
Effect levels (P0)
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 60 mg/kg bw/day (actual dose received)
- Sex:
- male
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 60 mg/kg bw/day (actual dose received)
- Sex:
- female
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
If weight changes qualify as toxicity, the NOAEL for reproductive organ toxicity is 60 mg/kg bw/d. These, however, are considered minor in the absence of histopathology. The overall NOAEL for systemic effects in the 90-day study is 20 mg/kg bw/d.
Applicant's summary and conclusion
- Conclusions:
- In a subchronic study of 2VP, male and female Sprague Dawley rats were administered test material by oral gavage 5 days per week, for 92 weeks, at doses of 120, 60 and 30 mg/kg bw/day. Food and water consumption, weight gain and body weights were tracked, and gross and histopathologic examinations were undertaken after sacrifice at 92 days. Food consumption, weight gain and body weight were significantly decreased among high dose animals. Relative organ weight changes in testis and ovaries were observed in high dose animals. No histopathologic effects were noted upon examination. Relative organ weights can indicate sparing of these organs when body weight decreases due to stress or chemical exposure. The NOAEL for reproductive organ toxicity can conservatively be 60 mg/kg bw/d. The overall NOAEL for the 90-day study is 20 mg/kg bw/d. This indicates that 2VP does not specifically promote reproductive toxicity.
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