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EC number: 222-981-6 | CAS number: 3687-46-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 23.5 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 75
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 33.33 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 300
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
The long-term systemic DNELs for workers are based on a subacute 28 day oral gavage study performed on Decyl oleate (CAS No.): 3687-46-5, in which the oral 28d NOAEL for rat was found to be 1000 mg/kg bw/day.
DNELs were derived based on guidance document R8 (ECHA 2008).
Long-Term exposure-Systemic effects.
Dermal DNEL:
Assessment factors: inter species 4; remaining differences 2.5, intra species factor 5, and exposure duration factor 6.
Overall AF= 300
Rat oral NOAEL = 1000 mg/ kg bw/day
A dermal absorption difference of 10% was used to modify the dose to the correct starting dose.
NAELcorr= 1000 mg/kg bw/d / 0.1 = 10000 mg/kg bw/day
DNEL = NAEL / AF = 10000 mg/kg bw/d / 300 = 33.3 mg/kg bw/day
Inhalation DNEL:
Assessment factors: inter species 2.5, intra species factor 5, and exposure duration factor 6.
Overall AF = 75
Rat oral NOAEL = 1000 mg/ kg bw/day
For calculating inhalation DNEL for workers, the oral NAELcorrneeds to be converted into an inhalatory NAECcorr rat by application of route-to route extrapolation:
NAECcorr= NAELcorr x 1/0.38 x 6.7/10 = 1763 mg/m3/d
DNEL = NAECcorr/ AF = 1763 mg/m3/ 75 = 23.5 mg/m3
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4.14 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 150
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 11.9 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 600
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.19 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 600
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
The long-term systemic DNELs for consumers are based on a subacute 28 day oral gavage study performed on Decyl oleate (CAS No.): 3687-46-5, in which the oral 28d NOAEL for rat was found to be 1000 mg/kg bw/day.
DNELs were derived based on guidance document R8 (ECHA 2008).
Dermal DNEL:
Assessment factors: inter species 4, remaining differences 2.5, intra species factor 10, and exposure duration factor 6.
Overall AF= 600
A dermal absorption difference of 10% and a factor of 5/7 (as the substance was adminstered 5 days/week) was used to modify the NOAEL to the correct starting dose. NAELcorr= 1000 x 5/7 / 0.1 = 7143 mg/kg bw/day
DNEL = NAEL / AF = 7143 mg/kg bw/d / 600= 11.9 mg/kg bw/day
Inhalation DNEL:
Assessment factors: inter species 2.5, intra species factor 10, and exposure duration factor 6.
Overall AF= 150
Rat oral NOAEL = 1000 mg/ kg bw/day
Since the substance was administered 5 days/ week a factor of 5/7 was used to modify the NOAEL to the correct starting dose. NAELcorr = 1000 mg/kg bw/d x 5/7 = 714.3 mg/kg bw/d
For calculating inhalation DNEL for consumers, the oral NAELcorr needs to be converted into an inhalatory NAECcorr rat by application of route-to route extrapolation:
NAECcorr= NAELcorr x 1 / 1.15 = 621.1 mg/m3
DNEL = NAECcorr / AF = 621.1 mg/m3/ 150 = 4.14 mg/m3
Oral DNEL:
Assessment factors: Inter species factor 2.5, allometric scaling factor 4, intra species factor 10, and exposure duration factor 6.
Overall AF= 600
The long-term DNELs are based on a subacute 28 day oral gavage study performed on Decyl oleate (CAS No.): 3687-46-5, in which the oral 28d NOAEL for rat was found to be 1000 mg/kg bw/day. A factor of 5/7 (substance was adminsitered 5 days/week) was used to modify the NOAEL to the correct starting dose.
NAELcorr= 1000 mg/kg bw/d x 5/7 = 714 mg/kg bw/day
DNEL = NAELcorr / AF = 714 mg/kg bw/d / 600=1.19 mg/kg bw/day
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