Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-826-1 | CAS number: 111-02-4
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: NTP study, performed following official guideline. No GLP reported
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
- Principles of method if other than guideline:
- Standard NTP protocol. See below for further information
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
- EC Number:
- 203-826-1
- EC Name:
- 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
- Cas Number:
- 111-02-4
- Molecular formula:
- C30H50
- IUPAC Name:
- 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Details on mammalian cell type (if applicable):
- No data
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9
- Vehicle / solvent:
- Acetone
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Acetone
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Strain: TA100 |
||
S9 Activation |
S9 Species |
Concentration |
No Activation |
N/A |
N/A |
30% RLI |
Rat |
30% |
30% HLI |
Hamster |
30% |
10% RLI |
Rat |
10% |
10% HLI |
Hamster |
10% |
Strain: TA1535 |
||
S9 Activation |
S9 Species |
Concentration |
No Activation |
N/A |
N/A |
30% RLI |
Rat |
30% |
30% HLI |
Hamster |
30% |
10% RLI |
Rat |
10% |
10% HLI |
Hamster |
10% |
Strain: TA97 |
||
S9 Activation |
S9 Species |
Concentration |
No Activation |
N/A |
N/A |
30% RLI |
Rat |
30% |
30% HLI |
Hamster |
30% |
10% RLI |
Rat |
10% |
10% HLI |
Hamster |
10% |
Strain: TA98 |
||
S9 Activation |
S9 Species |
Concentration |
No Activation |
N/A |
N/A |
30% RLI |
Rat |
30% |
30% HLI |
Hamster |
30% |
10% RLI |
Rat |
10% |
10% HLI |
Hamster |
10% |
Concentration denotes the the percentage of S9 in the S9 mixture (metabolic activation enzymes and cofactors from Aroclor 1254-induced male Sprague-Dawley rat or Syrian hamster liver) that was added to cultures
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
