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EC number: 629-721-4 | CAS number: 308062-60-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- pre-GLP, but inhouse quality insurance was in place
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- N-(C16-C18)alkyl(C16-C18)alkane-1-amine
- EC Number:
- 629-721-4
- Cas Number:
- 308062-60-4
- Molecular formula:
- No molecular formula
- IUPAC Name:
- N-(C16-C18)alkyl(C16-C18)alkane-1-amine
- Test material form:
- solid
- Details on test material:
- Chemical name: Amines, di-C16-18 (even numbered) alkyl
EC no.: 629-721-4
To the best of knowledge, the sample used is representative to the boundary composition shared and agreed by each registrant.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River U.K. Limited, Margate, Kent, England.
- Age at study initiation: 4-6 weeks
- Weight at study initiation: 101-122g
- Fasting period before study: Access to food only was prevented overnight prior to and approximately 4 hours after dosing.
- Housing: in groups by sex in metal cages with wire mesh floors.
- Diet (e.g. ad libitum): ad libitum, standard laboratory rodent diet (Labsure LAD 1)
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 9 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-22
- Humidity (%): 56
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: The study was undertaken between 8 and 22 May 1987.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50%
- Amount of vehicle (if gavage): 10.0 ml/kg max.
- Justification for choice of vehicle: no data
- Lot/batch no. (if required): no data
- Purity: no data
MAXIMUM DOSE VOLUME APPLIED:
10.0 ml/kg
DOSAGE PREPARATION (if unusual):
No data, the dosage was prepared on the day of dosing. - Doses:
- Preliminary and main study: 5000 mg/kg bw
- No. of animals per sex per dose:
- Preliminary study: 2
Main study: 5 - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 5days, preliminary study and 14 days, main study
- Frequency of observations and weighing: Animals were observed soon after dosing; then at frequent intervals for the remainder of Day 1. On
subsequent days the animals were observed once in the morning and again at the end of the experimental day. Clinical signs were recorded at each observation. Individual bodyweights of rats on Days 1 (day of dosing), 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed:- - Statistics:
- None
Results and discussion
- Preliminary study:
- No mortality at 5000 mg/kg bw
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality at 5000 mg/kg bw
- Clinical signs:
- other: Pilo-erection was observed in all rats shortly after dosing. There were no other clinical signs and recovery, as judged by external appearance and behaviour, was apparently complete by Day 2.
- Gross pathology:
- No effects observed
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The LD50 of Bis (hydrogenated tallowalkyl) amine is greather than 5000 mg/kg bw.
- Executive summary:
According to OECD401 rats were exposed to 5000 mg/kg bw. No deaths occured and no significant other effects were observed. The LD50 of Amines, di-C16-18 (even-numbered) alkyl (CAS No. 308062-60-4) is greather than 5000 mg/kg bw.
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