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EC number: 202-829-5 | CAS number: 100-20-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- Similar to, but not conducted under current guideline skin corrosion test methodology.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Skin Corrosion Test as defined in Department of Transportation Hazardous Materials Regulations, Title 49 CFR, Section 173.240(a)(1), December 31, 1973.
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Terephthaloyl dichloride
- EC Number:
- 202-829-5
- EC Name:
- Terephthaloyl dichloride
- Cas Number:
- 100-20-9
- Molecular formula:
- C8H4Cl2O2
- IUPAC Name:
- benzene-1,4-dicarbonyl dichloride
- Reference substance name:
- Terephthaloyl chloride
- IUPAC Name:
- Terephthaloyl chloride
- Details on test material:
- - Purity: 99.9%
- Impurities: Not reported
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Albino rabbits
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 2-3 kg
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 4 hours
- Observation period:
- Observations done at 4, 24 and 48 hours.
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: Back
- % coverage: 1.5 by 1.5 inch coverage
- Type of wrap if used: 12 ply cotton gauze pads then trunk of animal loosely wrapped with rubber sheeting.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes
- Time after start of exposure: 4 hours
SCORING SYSTEM: Not reported
Skin reactions were evaluated after removal of the wrapping. Readings were again made at 24 and 48 hours after the initial application.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: corrosion
- Basis:
- animal: 1 - 5
- Time point:
- other: 4, 24, 48 hours
- Remarks on result:
- other: no skin corrosion
- Irritation parameter:
- erythema score
- Basis:
- animal: 1-5
- Time point:
- 24 h
- Remarks on result:
- other: no skin corrosion
- Irritation parameter:
- erythema score
- Basis:
- animal: 1-5
- Time point:
- 48 h
- Remarks on result:
- other: no skin corrosion
- Irritation parameter:
- erythema score
- Basis:
- animal: 1-5
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal: 1-5
- Time point:
- 24 h
- Remarks on result:
- other: no skin corrosion
- Irritation parameter:
- edema score
- Basis:
- animal: 1-5
- Time point:
- 48 h
- Remarks on result:
- other: no skin corrosion
- Irritation parameter:
- edema score
- Basis:
- animal: 1-5
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritant / corrosive response data:
- No skin corrosion in any of the rabbits.
- Other effects:
- One rabbit died prior to 24-hour reading from non-compound related cause.
Any other information on results incl. tables
Hours after Initial Application |
Number of Rabbits with Skin Corrosion |
4 |
0/6 |
24 |
0/5 |
48 |
0/5 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Not corrosive to skin.
- Executive summary:
0.5 gm of the test substance was applied to a 1.5 by 1.5 inch area of the clipped dorsal skin of six albino rabbits. The treated area was covered with an occlusive dressing. After 4 hours, the wrapping was removed any skin reactions evaluated. The test sites were then washed. Readings were again made at 24 and 48 hours after the initial application. There was no skin corrosion. One rabbit died prior to the 24-hour reading from non-compound related cause. According to the Regulations of the Department of Transportation, the test substance is not corrosive to skin.
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