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EC number: 232-151-5 | CAS number: 7789-23-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Results of this study are scentifically acceptable, the testing procedures and resulting data are sufficient and well documented.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
- Reference Type:
- publication
- Title:
- Salmonella mutagenicity test results for 250 chemicals
- Author:
- Haworth, Steve, Timothy Lawlor, Kristien Mortelmans, William Speck and Errol Zeiger
- Year:
- 1 983
- Bibliographic source:
- Environmental Mutagenesis, Supplement 1: 3-142, 1983.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Ames Salmonella/mammalian microsome test
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Sodium fluoride
- EC Number:
- 231-667-8
- EC Name:
- Sodium fluoride
- Cas Number:
- 7681-49-4
- IUPAC Name:
- sodium fluoride
- Details on test material:
- - Name of test material (as cited in study report): sodium fluoride
- Analytical purity: 99%
- Lot/batch No.: DC 030887
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor 1254-induced male Sprague-Dawley rat or Syrian hamster liver S9
- Test concentrations with justification for top dose:
- 0, 100, 333, 1000, 3333 and 10000 ug NaF/plate
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: Dimethylsulfoxide
- Justification for choice of solvent/vehicle:
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Remarks:
- dimethylsulfoxide (DMSO)
- Positive controls:
- yes
- Positive control substance:
- other: 2-aminoanthracene was tested for all strains in the presence of S9. In the absence of S9, 4-nitro-o-phenylenediamine was tested with TA98, sodium azide was tested with TA100 and TA1535, and 9-aminoacridine was tested with TA1537.
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation); refer to Haworth (1983) for details
DURATION
- Preincubation period: 20 minutes at 37 degrees C
- Exposure duration: 48 hours
- Expression time (cells in growth medium):
NUMBER OF REPLICATIONS: Two
- Evaluation criteria:
- A positive response was defined as a reproducible, dose-related increase in histidine-independent (revertant) colonies in any one strain/activation combination. An equivocal response was defined as an increase in revertants that was not dose-related, not reproducible, or of insufficient magnitude to support a determination of mutagenicity. A negative response was obtained when no increase in revertant colonies was observed following chemical treatment.
- Statistics:
- Revertants were presented as mean +/- the SD from 3 plates.
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks:
- Sodium fluoride did not induce gene mutations in any of the strains of Salmonella t. tested
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Remarks:
- Definitive cytotoxicity was not observed in any Salmonella t. strains at doses up to 10,000 ug/plate
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'. Remarks: S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Sodium fluoride did not induce gene mutations in Salmonella typhimurium strains TA100, TA1535, TA1537 and TA98 when tested with a preincubation protocol at doses of 100 to 10,000 ug/plate. All strians were tested with or without Aroclor 1254-induced male Sprague-Dawley or Syrian hamster liver S9.
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