Registration Dossier
Registration Dossier
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EC number: 402-920-1 | CAS number: 103300-89-6 N-6-TRIFLUORACETYL-L-LYSYL-L-PROLIN; T.F.A. LYS PRO; TFA-LYS-PRO
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistance
The ready biodegradability of ε-trifluoracetyl-L-lysyl-L-proline (TFA-Lys-Pro) was investigated in a study according to OECD Guideline 301 E. The test item showed a degradation of 99 % after 28 d. As the 10 d window was met the substance is considered to be readily biodegradable. Based on this information the substance is not regarded as persistent.
Bioaccumulation
Bioaccumulation of the substance can be excluded based on its low logKow of -1.89
Toxicity
The substance is not classified as carcinogenic (Cat.1A or 1B) or toxic for reproduction (Cat.1A, 1B, or 2) according to regulation EC No. 1272/2008 (CLP), nor is there any evidence of chronic toxicity as identified by the classification as Specific Target Organ Toxicity after repeated exposure (STOT RE category 1 or 2) according to the same regulation.
Based on reliable results from short-term toxicity studies on algae, daphnids and fish the L(E)C50 values for the substance were determined to be >1000 mg/L.
In accordance with the decision tree depicted in section R11.1.3.3 of ECHA's "Guidance on information requirements and chemical safety assessment", acute toxicity results >0.1 mg/L lead to a screening assignement of "presumably not T".
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