Registration Dossier
Registration Dossier
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EC number: 457-320-2 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Systemic absorption of EC# 457-320-2 is expected to be limited due to the physical and chemical properties of the substance. Any substance that is absorbed is likely to partition preferentially to lipid-rich tissues. In the absence of notable metabolism, this could lead to bioaccumulation; however, the true potential for bioaccumulation is expected to be low due to the expected limited absorption potential.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
The physicochemical properties of EC# 457-320-2 (e.g. its molecular weight of 2,224) indicate its potential for absorption into the body will be limited. The repeat-dose oral toxicity data only found effects in the top dose group administered 1,000 mg/kg bw/day, which indicates the substance is absorbed through the gastrointestinal tract, but possibly only to a very limited extent. The absence of effects in the repeat-dose dermal toxicity study indicates that if any dermal absorption occurs at all, it occurs at a lower rate than oral absorption. The high partition coefficient indicates that any molecules that are absorbed will partition preferentially to lipid-rich tissues, and this is supported by the reproduction/developmental toxicity screening study which reported clinical observations suggestive of Central Nervous System toxicity at the top dose (1,000 mg/kg bw/day). The available environmental degradation data indicate that the substance is not readily biodegraded. If mammalian metabolism is similarly limited, this would suggest the potential for bioaccumulation. However, the true bioaccumulation potential is likely to be low, due to the limited absorption potential.
Discussion on bioaccumulation potential result:
The physicochemical properties of EC# 457-320-2 (e.g. its molecular weight of 2,224) indicate its potential for absorption into the body will be limited. The repeat-dose oral toxicity data only found effects in the top dose group administered 1,000 mg/kg bw/day, which indicates the substance is absorbed through the gastrointestinal tract, but possibly only to a very limited extent. The absence of effects in the repeat-dose dermal toxicity study indicates that if any dermal absorption occurs at all, it occurs at a lower rate than oral absorption. The high partition coefficient indicates that any molecules that are absorbed will partition preferentially to lipid-rich tissues, and this is supported by the reproduction/developmental toxicity screening study which reported clinical observations suggestive of Central Nervous System toxicity at the top dose (1,000 mg/kg bw/day). The available environmental degradation data indicate that the substance is not readily biodegraded. If mammalian metabolism is similarly limited, this would suggest the potential for bioaccumulation. However, the true bioaccumulation potential is likely to be low, due to the limited absorption potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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