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EC number: 232-145-2 | CAS number: 7789-17-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-10-09 to 2012-10-16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline compliant study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- (2002)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Version / remarks:
- (2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- Version / remarks:
- (1998)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Caesium iodide
- EC Number:
- 232-145-2
- EC Name:
- Caesium iodide
- Cas Number:
- 7789-17-5
- Molecular formula:
- CsI
- IUPAC Name:
- caesium iodide
- Test material form:
- other: solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: S & K LAP Kft. 2173 Kartal, Császár út 135, HUNGARY
- Age at study initiation: Young adult rabbits
- Weight at study initiation: 2870-2925 g
- Housing: Animals were housed individually in metal cages.
- Diet: Fattening mixed diet, ad libitum
- Water: Tap water, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3 °C
- Humidity (%): 30 - 70 %
- Air changes (per hr): 9-12 changes/hour
- Photoperiod: Artificial light, from 6 a.m. to 6 p.m.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: contralateral eye
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0. 1 g - Duration of treatment / exposure:
- In the first step an initial test was performed using one animal. The test item was firstly well grinded and was poured into the conjunctival sac of the left eye. The eyelids were held closed gently for several seconds to prevent the loss of the test item. The contralateral eye served as control. Immediately after the administration of the test item, an assessment of the initial pain reaction was made according to the six point scale.
After consideration of the ocular responses produced in the first animal, two additional animals were treated.
Before the administration, the eyes of the second and the third animal were not anaesthetised, because the score of initial pain reaction was 2 in the first animal. The eyes of the test animals were not washed out after the application of test item. - Observation period (in vivo):
- The eyes were examined at 1, 24, 48 and 72 hours after the application.
- Number of animals or in vitro replicates:
- 3 animals
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
None
SCORING SYSTEM: The eye irritation scores were evaluated according to the scoring system by Draize (1977) and OECD 405 (24th April 2002).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 24, 48, 72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: The max score gives the theoretically highest reachable score.
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- other: The max score gives the theoretically highest reachable score.
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 24h
- Score:
- 2
- Max. score:
- 3
- Remarks on result:
- other: The max score gives the theoretically highest reachable score.
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 48 h
- Score:
- 0.33
- Max. score:
- 3
- Remarks on result:
- other: The max score gives the theoretically highest reachable score.
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 72 h
- Score:
- 1
- Max. score:
- 3
- Remarks on result:
- other: The max score gives the theoretically highest reachable score.
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 24 h
- Score:
- 1.33
- Max. score:
- 4
- Remarks on result:
- other: The max score gives the theoretically highest reachable score.
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 48 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: The max score gives the theoretically highest reachable score.
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 72 h
- Score:
- 0.33
- Max. score:
- 4
- Remarks on result:
- other: The max score gives the theoretically highest reachable score.
- Irritation parameter:
- conjunctivae score
- Remarks:
- discharge
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 3
- Remarks on result:
- other: The max score gives the theoretically highest reachable score.
- Irritation parameter:
- conjunctivae score
- Remarks:
- discharge
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 48 h
- Score:
- 0.33
- Max. score:
- 3
- Remarks on result:
- other: The max score gives the theoretically highest reachable score.
- Irritation parameter:
- conjunctivae score
- Remarks:
- discharge
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 72 h
- Score:
- 1.33
- Max. score:
- 3
- Remarks on result:
- other: The max score gives the theoretically highest reachable score.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In conclusion, test item cesium iodide applied to the rabbits' eye mucosa, caused slight to severe conjunctival and slight corneal irritant effects, fully reversible within 1 week.
According to the Commission Directive 2001/59/EC criteria for classification and labelling requirements for dangerous substances and preparations, the test item does not have to be classified and has no obligatory labelling requirement for eye irritation.
According to Regulation (EC) No. 1272/2008, the test item has not been classified into any category. - Executive summary:
The eyes were examined at 1, 24, 48 and 72 hours then 1 week after the application. One hour after treatment, some hyperemic blood vessels (score 1) were observed in all animals. The obvious swelling with partial eversion of lids (score 2) was detected in animal No.: 1742 and the swelling was different from normal (score 1) in two animals (No.: 1735, 1732). The discharge with moistening of the lids and hairs just adjacent to lids (score 2) were observed in two animals (No.: 1742, 1735) and the discharge moistened lids and hairs on considerable area around the treated eye (score 3) was recorded in animal No.: 1732. Diffuse areas of opacity were detected and the details of iris were clearly visible (score 1) in two animals (No.: 1742, 1732). Area of cornea involved was greater than one quarter, but less than half (score 2) in both animals. 24 hours after treatment, some hyperemic blood vessels (score 1) were observed in two animals (No.: 1735, 1732) and diffuse, crimson coloured conjunctivae with not easily discernible individual vessels (score 2) occurred in animal No.: 1742. The obvious swelling with partial eversion of lids (score 2) was detected in animal No.: 1742 and the swelling was different from normal (score 1) in animal (No.: 1732). The discharge with moistening of the lids and hairs just adjacent to lids (score 2) were observed in two animals (No.: 1742, 1732) and the amount of the discharge was different from normal (score 1) in animal No.: 1735. Diffuse areas of opacity were detected and the details of iris were clearly visible (score 1) in animal No.: 1742. Area of cornea involved was at least one quarter, but not zero (score 1) in this animal. 48 hours after treatment, some hyperemic blood vessels (score 1) were observed in animal No.: 1732 and diffuse, crimson coloured conjunctivae with not easily discernible individual vessels (score 2) occurred in animal No.: 1742. The swelling was different from normal (score 1) in animal (No.: 1742). The discharge with moistening of the lids and hairs just adjacent to lids (score 2) were observed in animal No.: 1742 and the amount of the discharge was different from normal (score 1) in animal No.: 1732. 72 hours after the treatment, the state of animals was unchanged. 1 week after the treatment the study was terminated, since no primary irritation symptoms occurred. During the study the control eyes of the animals were symptom-free. General state and the behaviour of the animals were normal throughout the study period. There were no effects on body weight attributable to the treatment with the test item during the contact and observation period.
In conclusion, test item cesium iodide applied to the rabbits' eye mucosa, caused slight to severe conjunctival and slight corneal irritant effects, fully reversible within 1 week.
According to the Commission Directive 2001/59/EC criteria for classification and labelling requirements for dangerous substances and preparations, the test item does not have to be classified and has no obligatory labelling requirement for eye irritation.
According to Regulation (EC) No. 1272/2008, the test item has not been classified into any category.
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