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EC number: 201-222-2 | CAS number: 79-74-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 May 1980 to 13 May 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP study similar to OECD 202. No analytical determinations of the test substance.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- : no analytical determinations of the test substance
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Details on sampling:
- not applicable
- Vehicle:
- yes
- Details on test solutions:
- - vehicle: nanograde acetone
- dilution water: ABC well water
- maximum concentration of vehicle (=solvent control): 3.2 mg/L
- compound was found to form a floating white precipitate - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - source: in-house culture
- adult Daphnids were fed a suspension of trout chow and alfalfa (PR-11) daily, until 24 hours prior to testing - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 255 mg/L CaC03 (measured in well water, not measured during test)
- Test temperature:
- 20 ± 1 °C
- pH:
- 7.8 in control at start of test
8.3-8.4 in all treatments at end of test - Dissolved oxygen:
- 9.2 mg/L in control at start of test
8.7-8.8 mg/L in all treatments at end of test - Salinity:
- not applicable
- Nominal and measured concentrations:
- nominal concentrations: control, solvent control, 0.32, 0.56, 1.0, 1.8, 3.2 mg/L
measured concentrations: no analytics performed - Details on test conditions:
- - photoperiod: 16:8, light:dark
- test vessels: 250-mL glass beakers
- test volume: 200 mL
- n° replicates: 2
- 10 Daphnids per vessel
- Daphnids were < 24 hours old
- range-finding test:
* concentrations: 0.1, 1.0, 10 mg/L
* results: after 24 hours 8 dead organisms in 10 mg/L, after 48 hours 8 and 10 dead organisms in 1.0 and 10 mg/L, respectively
- temperature, dissolved oxygen and pH were measured in the control only at the start of the test, and measured in all other treatments after 48 hours - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.91 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95 % CL: 0.78-1.1 mg/L
- Details on results:
- Percent mortality after 24h: 0% in control, control+acetone, 0.32, 0.56 and 1.0 mg/L; 35% in 1.8 mg/L; 95% in 3.2 mg/L.
Percent mortality after 48h: 0% in control, control+acetone and 0.32 mg/L; 10% in 0.56 mg/L; 55% in 1.0 mg/L; 100% in 1.8 and 3.2 mg/L.
The test substance formed a floating white precipitate. - Results with reference substance (positive control):
- not applicable
- Reported statistics and error estimates:
- Binomial, moving average and probit tests were performed when appropriate.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Reliable study (Klimisch 2) reporting an LC50(48h) of 0.91 mg/L for Daphnia magna. The test compound was found to form a floating white precipitate.
- Executive summary:
The acute toxicity of Santovar A t o Daphnia magna was assessed using the methods outlined by the Commitee on Methods for Toxicity Tests with Aquatic Organisms. Water quality parameters of temperature, dissolved oxygen and pH were measured at the termination of the test and were within acceptable limits.
The results of the 48 hour static Daphnia magna toxicity study are summarized below.
Compound 48-hour LC50 (95% C.I.)
Santovar A 0.91 (0.78-1.1) mg/l
The no effect level observed for Santovar A was 0.32 mg/l after 48 hours.
Reference
Description of key information
A 48-h static exposure of Daphnia magna resulted in an LC50 value of 0.91 mg/L (ABC Laboratories, 1980, AB-80-395). The organisms were exposed to Santovar A, according to a test protocol which was similar to OECD 202 guideline, and mortality was observed. The LC50 value was derived based on nominal concentrations as no analytical measurements were performed.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.91 mg/L
Additional information
The only relevant study identified for the short-term toxicity to aquatic invertebrates was the study of Forbis and Boudreau by ABC Laboratories (1980, AB-80-395). As this study was found reliable with restrictions, its outcome can be used as key value.
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