Registration Dossier
Registration Dossier
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EC number: 220-358-3 | CAS number: 2736-23-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 30-09-1980 to 03-10-1980
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- CAS 2736-23-4
- IUPAC Name:
- CAS 2736-23-4
- Reference substance name:
- 2,4-dichloro-5-sulphamoylbenzoic acid
- EC Number:
- 220-358-3
- EC Name:
- 2,4-dichloro-5-sulphamoylbenzoic acid
- Cas Number:
- 2736-23-4
- Molecular formula:
- C7H5Cl2NO4S
- IUPAC Name:
- 2,4-dichloro-5-sulphamoylbenzoic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or test system and environmental conditions:
- The experimental animals were albino Himalayan rabbits (strain: Hoe: HIMK (SPFWiga); own breeding) used in weight from 1.846 to 2.392 kg. The animals were kept in individual cages and were given the standard feed ERKA 8300 (feed mill Robert Koch oHG, Hamm / Westphalia.). Food and water were available ad libitum.
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 24h
- Observation period:
- 24, 48 and 72h
- Number of animals:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Time point:
- other: 48 and 72 h
- Remarks on result:
- other: Irritation index 1.4
- Irritant / corrosive response data:
- After application, the pasted substance was determined to be irritant with index 1,4., In addition, a rabbit skin after 48 and 72h was dry, rough, scaly and superficially cracked. Another rabbit skin was dry, rough and scaly.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the available results, the substance is thus regarded as slightly irritating to skin.
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