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Diss Factsheets
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EC number: 234-148-4 | CAS number: 10563-29-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- chronic toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Dermal Oncogenicity Studies on Various Ethyleneamines in Male C3H Mice
- Author:
- De Pass LR, Fowler EH, and Weil CS
- Year:
- 1 987
- Bibliographic source:
- FUNDAMENTAL AND APPLIED TOXICOLOGY, 9, 807-811
Materials and methods
- Principles of method if other than guideline:
- Mice were dosed dermally three times/week for a lifetime. Gross and histopathological examinations were performed on all animals.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,2'-iminodi(ethylamine)
- EC Number:
- 203-865-4
- EC Name:
- 2,2'-iminodi(ethylamine)
- Cas Number:
- 111-40-0
- IUPAC Name:
- N-(2-aminoethyl)ethane-1,2-diamine
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: C3H/HeJ
- Sex:
- male
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- water
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- complete life span (ca. 20 months)
- Frequency of treatment:
- 3 times weekly
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
1.25 mg/animal
Basis:
other: nominal in water 25 µl in 5% solution v/v
- Remarks:
- Doses / Concentrations:
56.3 mg/kg bw
Basis:
other: Estimate as calculated from data from average of initial body weights and milligrams administered
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results of examinations
- Details on results:
- See section 7.7
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- >= 56.3 mg/kg bw/day
- Sex:
- male
- Basis for effect level:
- other: 3 times weekly
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
Diethylenetriamine (DETA) was tested in a total of 100 male C3H/HeJ mice in a study involving dermal application of two products of different degrees of purity, DETA High Purity (DETA-HP, 96.77% diethylenetriamine, 1.78% N-(2-aminoethyl)piperazine, remaining components other amines) and DETA Commercial Grade (DETA-C 90.8% diethylenetriamine, 8.9% N-(2-aminoethyl)piperazine, 0.34% ethylenediamine). The test substances were applied as a 5% aqueous solution. A 10% diethylenetriamine solution had caused open skin wounds, and so the non-irritating 5% solution was considered to be the highest possible concentration that could be used in a lifetime study. The treatment involved the application of 25 µl of the test solution (1.25 mg) to the dorsal skin of the mice (which was shaved once a week) three times a week for their entire lives. The mice were observed daily. After 18 months, the skin, liver, kidneys and lungs from 10 mice/group were fixed for histological examination. The average survival time for the mice was 587 days in the DETA-HP group and 662 days in the DETA-C group. The animals in the control group, which were treated with 25 µl water, lived for 626 days on average. 2 tumours were found in total. One mouse in the control group had a sebaceous gland adenoma of the thorax, and one in the DETA-C group had a cavernous haemangioma of the neck region. This type of haemangioma was also observed in historical controls in the institute carrying out the study. Also the effects on other organs corresponded to the spontaneous occurrence in the control groups of the strain studied. Diethylenetriamine thus had no carcinogenic activity in this study.
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