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Diss Factsheets
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EC number: 608-356-4 | CAS number: 2941-20-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study conducted unter GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 1-phenylpropan-1-amine
- EC Number:
- 608-356-4
- Cas Number:
- 2941-20-0
- Molecular formula:
- C9 H13 N
- IUPAC Name:
- 1-phenylpropan-1-amine
- Test material form:
- other: solution in olive oil DAB 10
- Details on test material:
- Name of test substance: 1-Phenylpropylamin
Substance number: 97/98
Batch number: K 67/ 11.2.97/ Fr. 5
CAS number: 2941-20-0
Degree of purity/content: 99.7 g/100 g (GC)
Date of manufacturing: 11-Feb-1997
Physical state/appearance: Liquid, colourless
Storage conditions: Room temperature, exclusion of oxygen (store
under nitrogen)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Doses:
- 200, 500, and 2000 mg/kg bw
- No. of animals per sex per dose:
- 200 mg/kg bw: 3 male animals
500 mg/kg bw: 3 male animals
2000 mg/kg bw: 3 male and female animals - Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 500 mg/kg bw
- Mortality:
- 200 mg/kg bw: no mortality after 14 days
500 mg/kg bw: 3/3 found dead
2000 mg/kg bw: 3/3 found dead - Gross pathology:
- animals that died: glandular stomach: severe hyperemia; small intestine: hyperemia of the mucosa
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study the median lethal dose of (R)-1-Phenylpropylamin after oral application was found to be greater than
200 mg/kg and less or equal to 500 mg/kg body weight. - Executive summary:
To two groups each of three fasted animals (males) a single oral dose of the test material preparation in olive oil DAB 10 at dose levels of 500 and 2000 mg/kg body weight was given. Another group of six fasted animals (3 males and 3 females) was treated in the same way with a dose of 200 mg/kg body weight. Signs of toxicity noted in the 2000 and 500 mg/kg dose group comprised poor general state, dyspnoea, apathy, ataxia and paresis. Twitching, saltatory spasm and flexion spasm were additionally observed in rats of the 2000 mg/kg dose group. Symptoms observed in the 200 mg/kg dose group comprised impaired or poor general state, dyspnoea, apathy and staggering. The surviving animals appeared normal within 5 hours after application. The expected body weight gain was observed in the course of the study. All animals of the 500 and 2000 mg/kg dose group died within 1 hour after application. No mortality occurred in the 200 mg/kg dose group.
Necropsy findings of the animals that died comprised severe hyperemia in the glandular stomach and hyperemia of the mucosa in the small intestine (2000 mg/kg). No abnormalities were noted at necropsy of animals sacrificed at the end of the study and of the animals of the 500 mg/kg dose group that died. Under the conditions of this study the median lethal dose of (R)-1-Phenylpropylamin after oral application was found to be greater than 200 mg/kg and less or equal to 500 mg/kg body weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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