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EC number: 291-169-1 | CAS number: 90342-32-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to an appropriate test protocol and in compliance with GLP. The study is read-across from 1-decanol (CAS 112-30-1).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2600 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- Buehler test
Test material
- Reference substance name:
- Decan-1-ol
- EC Number:
- 203-956-9
- EC Name:
- Decan-1-ol
- Cas Number:
- 112-30-1
- Molecular formula:
- C10H22O
- IUPAC Name:
- decan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Alfol 10
- Physical state: colourless liquid, sweet pungent odour
- Storage condition of test material: room temperature
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Elm Hill Breeding Labs., Chelmsford, MA
- Age at study initiation: young adult
- Weight at study initiation: 357-449g
- Housing: group-housed in suspended stainless steel caging with mesh floors or plastic perforated bottom caging.
- Diet: Pelleted Purina Guinea Pig Chow ad libitum
- Water: filtered tap water, ad libitum
- Acclimation period: 4-17 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-22
- Humidity (%): 56-79
- Photoperiod (hrs dark / hrs light): 12/12
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: mineral oil
- Concentration / amount:
- 0.4ml of undiluted test material was used for the induction phase.
0.4 ml of a 25% w/w mixture of the test substance in mmineral oil was used for the challenge phase.
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: mineral oil
- Concentration / amount:
- 0.4ml of undiluted test material was used for the induction phase.
0.4 ml of a 25% w/w mixture of the test substance in mmineral oil was used for the challenge phase.
- No. of animals per dose:
- Preliminary irritation group:4
Test group: 10
Naive control group: 10 - Details on study design:
- INDUCTION PHASE:
Once each week for three weeks, 0.4ml of the undiluted test substance was applied to the left side of each test animal using an occlusive 25 mm Hill Top CHamber. The chambers were secured in place and wrapped with adhesive tape to avoid dislocation of the chambers and to minimize loss of the test substance. After the 6
h exposure period, the chambers were removed and the test sites were gently cleansed with a 3% soap solutionh followed by tap water using a clean paper towel to remove any residual test substance. Approximately 24 and 48 hours after each induction application, readings were made of local reactions (erythema).
CHALLENGE PHASE:
Twenty-seven days after the first induction dose, 0.4 ml of a 25% w/w mixture of the test substance in mineral oil was applied to a naive site on the right side of each animal as a challenge dose, using the procedures described above. These sites were evaluated for a sensitization response (erythema) approximately 24 and 48 hours after the challenge application. - Challenge controls:
- In addition to the test animals, 10 guinea pigs from the same shipment were maintained under identical environmental conditions and were treated withe mineral highest non irritating concentration of the test substance at challenge only.
- Positive control substance(s):
- yes
- Remarks:
- alpha-Hexylcinnamaldehyde technical
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- rechallenge
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.4ml 25% w/w mixture of substance
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- very faint erythema present in some of the animals
- Remarks on result:
- other: Reading: rechallenge. . Hours after challenge: 24.0. Group: test group. Dose level: 0.4ml 25% w/w mixture of substance. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: very faint erythema present in some of the animals.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Based on the available information, the test substance was found not sensitizing to guinea pig skin.
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