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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

Currently viewing:

Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
other: QSAR toolbox
Title:
QSAR Study for 2580-78-1
Year:
2011
Bibliographic source:
OECD QSAR toolbox version 2.2, 2011; National Institute of Technology and Evaluation Japan; Research Institute for Animal Science in Biochemistry & Toxicology; 2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
GLP compliance:
not specified
Limit test:
yes

Test material

Constituent 1
Reference substance name:
2-(3-(4-amino-9,10-dihydro-3-sulpho-9,10-dioxoanthracen-4-yl)aminobenzenesulphonyl)vinyl) disodium sulphate
EC Number:
219-949-9
EC Name:
2-(3-(4-amino-9,10-dihydro-3-sulpho-9,10-dioxoanthracen-4-yl)aminobenzenesulphonyl)vinyl) disodium sulphate
Cas Number:
2580-78-1
IUPAC Name:
disodium 1-amino-9,10-dioxo-4-[(3-{[2-(sulfonatooxy)ethyl]sulfonyl}phenyl)amino]-9,10-dihydroanthracene-2-sulfonate
Details on test material:
Purity- 77.1

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Duration of treatment / exposure:
Administration period- 28 days
Doses / concentrations
Remarks:
Doses / Concentrations:
40 - 1000 mg/kg
Basis:
no data

Results and discussion

Results of examinations

Details on results:
Recovery period (day):14

Effect levels

Dose descriptor:
NOEL
Effect level:
1 000 other: mg/kg/day
Based on:
test mat.
Sex:
male
Basis for effect level:
other: Death, Increased body weight, Decreased body weigh, Increased food consumption, Decreased food consumption, Hyperthermia,Hypothermia

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Repeated dose toxicity value of the substance on rat(male) is NOEL:1000 mg/kg/day.