Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 616-291-8 | CAS number: 76114-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997-02-17 to 1997-05-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well documented GLP based study in accordance to EPA standard guideline
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1175 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 2-propynyl-butylcarbamate
- EC Number:
- 616-291-8
- Cas Number:
- 76114-73-3
- Molecular formula:
- C8H13NO2
- IUPAC Name:
- 2-propynyl-butylcarbamate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): only common name based on sponsor informaion is given, equivalent to:
Chemical name: Carbarmic acid, N-butyl-,2-propyn-1-yl ester
CAS: 76114-73-3
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace Animals, Inc., in Boyertown, PA
- Age at study initiation: approximately 6 to 10 weeks
- Weight at study initiation: 208 to 234 g
- Fasting period before study: yes for 18 hours
- Housing: stainless steel cages with indirect bedding
- Diet: ad libitum: Lab Diet Certified Rodent Diet 5002
- Water: ad libitum
- Acclimation period: 8 days prior to test initiation
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18.3 -23.8 °C (65° to 75° F)
- Humidity (%): humidity was monitored
- Photoperiod (hrs dark / hrs light):12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
- test item was used as received for the initial dose (group 1: 2000 mg/kg bw)
Administration volume: 2 ml/kg bw. - Doses:
- group 1: initial dose (= limit dose): 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were performed at 1,3,6 and 24 hours post-dosage and daily thereafter for at total of 14 days. Bodyweights were recorded on day 7 after exposure and at termination of the study.
- Necropsy of survivors performed: yes ( also any non-survivors)
- Sacrificing: with carbon dioxide asphyxiation
- Other examinations performed: clinical signs, body weight, histopathology - Statistics:
- -no special statistics applied
Results and discussion
- Preliminary study:
- At the initial dose of 2000 mg/kg bw 4/5 males and 5/5 females died on day 2 to day 4 after exposure. All animals suffered depressions before.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- < 2 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 2000 mg/kg bw: 80% mortality males and 100 % females (rats died on day 2 to 4 after exposure)
- Clinical signs:
- other: 2000 mg/kg bw: All rats showed slight or severe depressions on day 2 and 3 after exposure and before dead; one survivor did not show any clinical signs after day3 of exposure. Also diarrhea and muscle tremors have been observed. 1 g/kg bw: All rats showe
- Gross pathology:
- The small intestine of rats appeared severely reddened and sometimes ulcerated.
Applicant's summary and conclusion
- Conclusions:
- According to the guideline, the oral LD50 of Propargyl-N-butylcarbamat is less than 2000 mg/kg bw.
- Executive summary:
The acute oral toxicity of Propargyl-N-butylcarbamat
was determined in rats according to the EPA guideline OTS 798.1175. The LD50 was found to be smaller than the limit dose of 2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.