Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-165-4
CAS number: 2649-76-5
No internal acute toxicity studies of aldonaethylenolether are available. Results of an acute oral toxicity study are cited in RTECS database (Juli 2011):Oral (rat): LD (lethal dose) > 3000 mg/kg(Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third. Ave., New York, NY 10128) V.1- 1990- v. 1, p. 156, 1992 (ATDAEI))
Results of an acute toxicity study with aldonaethylenolether are cited
in RTECS database (Juli 2011):
Oral application of aldonaethylenolether to rats results in LD > 3000
mg/kg [Acute Toxicity Data. Journal of the American College of
Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third. Ave., New York,
NY 10128) V.1- 1990- v. 1, p. 156, 1992 (ATDAEI)]
Additionally, GLP-guideline studies with aldona, the pharmacological
active metabolite of aldonaethylenolether, were conducted.
The single oral administration of aldona to male and
female Wistar rats (3/sex) at the dose of 2000 mg/kg resulted in
transient rough hair coat, apathy, squatting position, decreased body
temperature only in females shortly after administration. No mortalities
occurred and no compound-related macroscopic findings were seen. The LD50
was determined to be above 2000 mg/kg [Schering AG, Report No. A03235;
2001-02-26; OECD TG 423]
The single dermal application of aldona to rats (3/sex) for 24 hours
(occlusively) did not induce any clinical or pathological signs. Again,
the LD50 was determined to be above 2000 mg/kg [Schering AG, Report No.
A03234; 2001-02-26; OECD TG 402].
Based on the study results a classification according to Directive
67/548/EEC and Regulation (EC) 1272/2008 (CLP) is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Tato webová stránka používá cookies, aby se vám naše stránky používaly co nejlépe.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again