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EC number: 937-237-2 | CAS number: 1370006-50-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Bioaccumulation of Partially unsaturated IQAC, DMS quaternised is unlikely. Considering the rapid hydrolysis at pH 7 (2.9 days) and pH 9 (1.2 days) as well as the inherent biodegradability, demonstrating the ability of organisms to metabolize the substance, a relevant bioaccumulation potential of partially unsaturated IQAC, DMS quaternised is not expected.
This is also supported by the outcome of three toxicokinetical studies with mammals (rats) made with radiolabelled IQAC, DMS quaternised (3 tests, 1.: Oleic acid based IQAC, 2.: tallow acid based IQAC and 3.: hydrogenated tallow acid based IQAC). The toxicokinetical studies resulted in poor absorption (dermal and intestinally) and fast elimination of the small amount of substance being absorbed (see 5.1.3. Summary and discussion of toxicokinetics).
The expectation of no relevant bioaccumulation of the substance is also supported by a modelling approach performed by Meylan et al. (1999). To develop a model on bioaccumulation, Meylan et al. (1999) collected measured BCF (sources: AQUIRE, CITI, HSDB and EFDB), log Kow (sources: MEDCHEM 'star list', Sangster's LOGKOW DATABANK or sources referenced in the EFDB or KOWWIN estimates), and pKa values for ionizing substances (sources: SRC's PHYSPROP database, compilation of Perrin and Serjeant and Dempsey and reference handbooks such as Handbook of Organic Chemistry, the Handbook of Chemistry and Physics and other sources cited in the EFDB or calculated using pKalc 3.1 software or SPARC). The database of 694 compounds with recommended BCF values contained 84 compounds defined as ionic, including carboxylic acids, sulfonic acids, and quaternary ammonium compounds. Based on the correlation of measured log BCF values and log Kow, log BCF values were deduced. The results were used to develop the computer program BCFWIN. BCFBAF, an update of the original BCFWIN program, was used to calculate the BCF values for the partially unsaturated IQAC, DMS quaternised. For the update, a more recent and better evaluated database of BCF values was used for both training and validation. The BCF data were re-regressed using the same methodology as in the original BCFWIN program. (The original estimation methodology used by the original BCFWIN program is described in a document prepared for the U.S. Environmental Protection Agency (Meylan et al., 1997). The estimation methodology was then published in journal article (Meylan et al, 1999).) The calculation yielded values in the range between 1 (Arnot-Gobas calculation method (upper trophic)) and 71 L/kg wet-wt (regression based calculation method). Based on the calculated BCFs a low potential for bioaccumulation is to be expected for partially unsaturated IQAC, DMS quaternised.
A measured BCF of partially unsaturated IQAC, DMS quaternised of 10.7 is the result of an open domain study with a closely related structural homologue (partially unsaturated IQAC, DMS quaternised, CAS-No. 68122-86-1), cited by NICNAS (1999). This homologue has been tested in a study with bluegill sunfish in a flow through system. The study is indicating a low bioaccumulation potential (BCF = 10.7) of IQAC.
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