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Diss Factsheets
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EC number: 215-137-3 | CAS number: 1305-62-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Outdated technology and examinations, no doses specified.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The Prevention of Silicosis: Experimental Investigations on the Action of Certain Non-Siliceous Dusts and Silica in the Origin and Development of Silicosis
- Author:
- Naeslund C
- Year:
- 1 940
- Bibliographic source:
- Ind. Hyg. Toxicol 22: 1-30
- Reference Type:
- secondary source
- Title:
- The Prevention of Silicosis: Experimental Investigations on the Action of Certain Non-Siliceous Dusts and Silica in the Origin and Development of Silicosis
- Author:
- Naeslund C
- Year:
- 1 940
- Bibliographic source:
- cited in: TNO BIBRA International Ltd., Toxicity Profile Calcium hydroxide, 1988
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data
- GLP compliance:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- - Test substance: Cement
Constituent 1
Test animals
- Species:
- other: rabbits and guinea pigs
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Details on inhalation exposure:
- These tests were carried out on the whole according to the same technic as earlier investigations concerning the promotive capacity of certain iron ores and granite leptite for silicosis (Naeslund, 1938).
Some changes were made however, to enable the simultaneous execution of a great number of exposures. By means of good-sized, strong fans, the finely powdered dusts were distributed in 6 different chambers of iron plate equipped with a lid of glass, in each of which up to 10 animals (rabbits and guinea pigs) were placed.
The arrangements with dust flasks, heating, agitation and taking of samples were the same. On the other hand, the percentage of dust was considerably increased and amounted, as a rule, to between 500,000 to 5,000,000 articles (under 10 µm in size) per cubic centimeter. The time of exposure in these dust chambers was not more than approximately 5 hours daily in order to render possible two (sometimes three) different series of tests in each chamber the same day. This was necessary because of the long experimental period and the large number of series. - Duration of treatment / exposure:
- Rabbit: 6 months, 2 days
Rabbit: 4 months, 18 days
Guinea pig: 8 months, 14 days - Frequency of treatment:
- 5 h/d
Doses / concentrations
- Remarks:
- Doses / Concentrations:
500000 - 5000000 particles/cm3
Basis:
- No. of animals per sex per dose:
- 2 rabbits and 1 guinea pig
- Details on study design:
- Rabbits and guinea pigs were exposed daily for 5 h to a poorly-defined concentration of calcium hydroxide dust.
Results and discussion
Results of examinations
- Details on results:
- The exposure seemed to predispose the animals to a variety of fatal lung infections. Structural changes (epithelial proliferation and thickening of the alveolar walls) in the lungs were seen in a guinea pig that survived exposure for 8.5 months and in two rabbits that survived after an exposure of 4.5 or 6 months.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.