Registration Dossier
Registration Dossier
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EC number: 420-680-6 | CAS number: 134127-48-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- The purpose of the study was to determine the estimated single dose oral LD50 of the test compound in male and female rats and the clinical signs of toxicity associated with a single oral dose.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 420-680-6
- EC Name:
- -
- Cas Number:
- 134127-48-3
- Molecular formula:
- C47 H47 Cl N2 O3 S
- IUPAC Name:
- 2-{2-[2-chloro-3-(2-{1,3,3-trimethyl-1H,2H,3H-benzo[g]indol-2-ylidene}ethylidene)cyclohex-1-en-1-yl]ethenyl}-1,1,3-trimethyl-1H-benzo[e]indol-3-ium 4-methylbenzene-1-sulfonate
- Details on test material:
- The identity of the test material concerns the same ECnumber as the substance in section 1. The purity of the test material is not described in the report, and thus might differ from the purity of the substance in section 1.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD (SD) BR VAF/Plus
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5% aqueous suspension of guar gum
- Doses:
- single dose: 25% suspension of test substance in vehicle
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: lethal dose
- Effect level:
- 5 000 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: 2 males and no females died at 5000mg/kg bw on day 10
- Mortality:
- One of five males died prior to clinical examinations on day 10 and a second male died shortly thereafter.
Treatment-related observations noted at necropsy of these two males included test material in the gastrointestinal tract, discoloration of the non-glandular gastric mucosa by the test material, and signs of cachexia. - Clinical signs:
- other: Abnormal clinical signs included discolored (red) feces, diarrhea, decreased feces, dehydration, and slight to moderate weakness.
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
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