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EC number: 252-471-9 | CAS number: 35265-04-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The data available on 2-[(1-methylpropyl)amino]ethanol and the estimations from its physico-chemical properties indicate a significant absorption by oral, dermal and inhalation routes of exposure, widespread distribution, rapid metabolism by oxidation and no bioaccumulation potential of parent and transformation products.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
There is no toxicokinetics, metabolism and distribution data available on 2-[(1-methylpropyl)amino]ethanol. Therefore, the assessment of the toxicokinetics of 2-[(1-methylpropyl)amino]ethanol is based on the available toxicological data and the physicochemical properties as suggested by the REACH Guidance Chapter R.7c:
Molecular weight: 117.19 g/mole
Water solubility: 544 g/L at 20°C ± 1°C
Partition coefficient log Kow = 0.4
ABSORPTION
Oral route
According to the REACH Guidance, the physicochemical characteristics of 2-[(1-methylpropyl)amino]ethanol (log Pow 0.4) and the molecular mass (117.19 g/mol) are in a range suggestive of absorption as such from the gastro-intestinal tract subsequent to oral ingestion. This assumption of oral absorption is confirmed by the mortality observed at 2000 mg/kg bw in the acute oral toxicity study (Pelcot, 2010) and at 1000 mg/kg bw/d in the oral 2-week toxicity study (Spezia, 2011b).
Therefore, the oral absorption of 2-[(1-methylpropyl)amino]ethanol can be assumed to be 100% for risk assessment.
Inhalation route
According to the REACH Guidance, the physicochemical characteristics of 2-[(1-methylpropyl)amino]ethanol (log Pow 0.4) and the molecular mass (117.19 g/mol) are in a range suggestive of absorption as such from the respiratory subsequent to inhalation exposure. This assumption of absorption is confirmed by the clinical signs of toxicity observed at 0.76 mg/L in the acute inhalation toxicity study (Schuler, 2012). Therefore, the inhalation absorption can be assumed to be 100% for risk assessment.
Dermal absorption
According to the REACH Guidance, the n-Octanol/water partition coefficient ((log Pow), the water solubility and molecular weight of2-[(1-methylpropyl)amino]ethanol are in ranges which favour dermal absorption. In such circumstances, a default value of 100% skin absorption is generally used.
DISTRIBUTION and METABOLISM
According to the REACH Guidance, as a small molecule a wide distribution of 2-[(1-methylpropyl)amino]ethanol is expected.
The major routes of metabolism of secondary amines involve various oxidative processes, including N-oxidation and dealkylation followed by deamination and conjugation, and other enzyme-catalyzed reactions leading to detoxification and excretion. Additionally, N-acetylation (a genetically regulated process in humans) may occur, but represents only a very minor pathway in the metabolism of aliphatic amines.
In animals, aliphatic amines are metabolized to carboxylic acid and urea. For secondary amines, metabolic intermediates are the corresponding aldehyde and ammonia. Metabolic pathways involved include (1) monoamine oxidase deamination; (2) diamine oxidase deamination; (3) N-dealkylation by cytochrome-P450; N-oxidation by cytochrome P-450 to the nitrone; and (4) N-oxidation by microsomal flavin-containing monooxygenase (FMO).
ELIMINATION
According to the REACH Guidance, the n-Octanol/water partition coefficient (log Pow of 0.4) is not suggestive of accumulation of unchanged 2-[(1-methylpropyl)amino]ethanol in fatty tissues subsequent to absorption.
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