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EC number: 907-495-0 | CAS number: 198028-14-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 December 2013
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Version / remarks:
- 1984
- GLP compliance:
- yes
- Remarks:
- According to “The guidelines for the testing of chemical (HJfT 153-2004)" and "The guidelines of chemical testing good laboratory practices (HJT 155)" issued by State Environmental Protection Administration (SEPA) of the People's Republic of China.
- Analytical monitoring:
- not required
- Vehicle:
- no
- Remarks:
- The test item was directly added into the soil.
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- TEST ORGANISM
- Source: the worms were obtained from an earthworm nursery of Nanjing in China.
- Age at test initiation (mean and range, SD): adult (two months old with clitellium).
- Weight at test initiation (mean and range, SD): adult with average weight of 388 mg.
ACCLIMATION
- Acclimation period: before the test, the worms were aclimated in no polluted soil for 24 days.
- Acclimation conditions (same as test or not): the worms were then pre-cultured in test soils another 24 hours. The worms were washed quickly with distilled water and surplus water absorded on filter paper before use.
- Health during acclimation (any mortality observed): not reported. - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- yes
- Total exposure duration:
- 14 d
- Test temperature:
- 20°C - 22°C
- pH:
- pH 6 - 6,3
- Moisture:
- 31% - 36%
- Details on test conditions:
- TEST SYSTEM
- Amount of soil or substrate: 740 g dry weight of soil for each container.
- No. of organisms per container (treatment): 10 individuals.
- No. of replicates per treatment group: 4
- No. of replicates per control: 4
OTHER TEST CONDITIONS
- Photoperiod: continuous light
- Light intensity: 400 - 800 Lux /
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality
TEST CONCENTRATIONS
- Range finding study : a pre-test was performed with test substance concentrations of 10, 100 and 1000 mg/kg artificial soil (dry weight).
- Results used to determine the conditions for the definitive study: no effects were observed in the range finder. - Nominal and measured concentrations:
- BAsed on the result of the range-finding test, a limit test was undertaken with test substance concentration of 1000 mg/kg dw of soil and a blank control.
- Reference substance (positive control):
- yes
- Remarks:
- 2-Chloracetamide (CAS 79-07-2), Purity > 98.5% Lot 20070329.
- Key result
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Basis for effect:
- mortality
- Details on results:
- - Behavioural abnormalities: None. During the test, all earthworms remained in the soil.
- Results with reference substance (positive control):
- The LC50 of a reference substance (2-chloracetamide) were determined to assure that the laboratory test conditions were adequate and had not changed significantly. For more details, please see the attached document containing all the biological results of this study.
- Reported statistics and error estimates:
- The LC50 and 95% confidence limits can be used to calculate by Trimmed Spearman-Karber Method (version 1.5 USEPA).
- Validity criteria fulfilled:
- yes
- Conclusions:
- During this test, artificial soils was used with the moisture content of the test medium controlled in range of 31 % to 36% with pH from 6.0 to 6.3. The test conditions were maintained as follows: temperature of 20°C to 22°C humidity of 80% to 85% and continuous light with intensity of 400 lux to 800 lux.
The result indicated that the 14 d-LC50 of the test substance in the artificial soil was greater than 1000 mg/kg dry weight soil. According to the test result, no effect was observed at the highest dose tested (1000 mg/kg dry weight). - Executive summary:
The test was conducted to determine the acute toxicity of test substances (99422018) to earthworm according to "The guidelines for the testing of chemicals" (HJ/f 153-2004) and "The guidelines for the testing of chemicals" (SEPA. Beijing: China Environmental Sciences Press. 2004); while with reference to Procedure 207 of the 'Guidelines for Testing of Chemicals' of the OECD: "Earthwonn, Acute Toxicity Tests" (1984) etc.
During this test, the artificial soils was used with the moisture content of the test medium controlled in range of 31 % to 36% and pH from 6.0 to 6.3 The test conditions were maintained as follows: temperature of 20°C to 22°C, humidity of 80% to 85% and continuous light with intensity of 400 lux to 800 lux.
Based on the result of range-finding test and the Limit Test, the 14 d-LC50 of the test substance in the artificial soil was determined to be greater than 1000 mg/kg dry weight soil. According to the test result, no effect was observed at the highest dose tested (1000 mg/kg dry weight).
Reference
pH and Moisture content of the artificial soil :
Concentration applied to soil (mg/kg (dry soi!)) | pH | Moisture content CD(%) | ||
0 d | 14 d | 0 d | 14 d | |
0 | 6.0 | 6.2 | 36 | 32 |
0 | 6.1 | 6.3 | 32 | 36 |
0 | 6.2 | 6.0 | 32 | 34 |
0 | 6.3 | 6.0 | 36 | 32 |
1000 | 6.0 | 6.3 | 33 | 34 |
1000 | 6.1 | 6.2 | 35 | 33 |
1000 | 6.3 | 6.3 | 36 | 36 |
1000 | 6.1 | 6.2 | 35 | 31 |
Min | 6 | 6 | 32 | 31 |
Max | 6.3 | 6.3 | 36 | 36 |
Description of key information
A key study according to the TG OECD 207 is available on terrestrial earthworms, no acute effect was observed at the highest dose tested (14 d - LC50 > 1000 mg/kg dw).
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 1 000 mg/kg soil dw
Additional information
According to the REACH guidance document R7c page 158, the registered substance has a log Kow > 5 and is not toxic according to the terrestrial ITS. Therefore it falls into the Soil Hasard Category 3 and a TG OECD 216 should be performed. Actually no toxicity on terrestrial macroorganisms is needed. However a study is available according to a TG OECD 207 and China GLP. No acute effects on terrestrial earthworms were observed, the endpoint is LC50 > 1000 mg/kg dw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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