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Diss Factsheets
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EC number: 248-273-7 | CAS number: 27157-94-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- SEP 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Due to variability and/or an increase in concentration between the 0 hours and 120 hours results, additional samples were taken after 144 hours (pH 4, 7 and 9); 168 and 264 hours (pH 4 and 7).
- Buffers:
- Sterile buffer solutions at pH's 4, 7 and 9.
Specification of buffer solutions (Concentration in mmol dm-3):
pH 4: Citric acid 0.6; Sodium chloride 0.4; Sodium hydroxide 0.7
pH 7: Disodium hydrogen orthophosphate (anhydrous) 0.3; Potassium dihydrogen orthophosphate 0.2; Sodium chloride 0.2
pH 9: Disodium tetraborate 0.1; sodium chloride 0.2 - Duration:
- 264 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 0.001 - <= 0.001 g/L
- Duration:
- 264 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 0.001 - <= 0.001 g/L
- Duration:
- 144 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 0.001 - <= 0.001 g/L
- Number of replicates:
- 2 replicates per pH value
- Positive controls:
- not specified
- Negative controls:
- not specified
- Preliminary study:
- Sample solutions at pH 4, 7 and 9 were maintained at 50.0 ± 0.5 °C for a period of at least 120 hours. The decrease in concentration was less than 10 % and no further testing was nessecary.
- Transformation products:
- not specified
- % Recovery:
- >= 93 - <= 94.4
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 264 h
- % Recovery:
- >= 97.1 - <= 125
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 264 h
- % Recovery:
- >= 116 - <= 121
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 144 h
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Remarks on result:
- other: Estimated from results at 50 °C
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Remarks on result:
- other: Estimated from results at 50 °C
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Remarks on result:
- other: Estimated from results at 50 °C
- Validity criteria fulfilled:
- yes
- Conclusions:
- It was determined that test item is not hydrolyzed at pH 4, 7 and 9 and the half-life is expected to be greater than 1 year at 25 ºC.
- Executive summary:
The hydrolysis of test item was determined according to OECD Guideline 111, under GLP compliance. It was determined that test item is not hydrolyzed at pH 4, 7 and 9 and the half-life is expected to be greater than 1 year at 25 ºC.
Reference
Description of key information
The hydrolysis of test item was determined according to OECD Guideline 111, under GLP compliance. It was determined that test item is not hydrolyzed at pH 4, 7 and 9 and the half-life is expected to be greater than 1 year at 25 ºC.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.