Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-662-1 | CAS number: 487-68-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study, available as unpublished report, no restrictions, fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,4,6-trimethylbenzaldehyde
- EC Number:
- 207-662-1
- EC Name:
- 2,4,6-trimethylbenzaldehyde
- Cas Number:
- 487-68-3
- Molecular formula:
- C10H12O
- IUPAC Name:
- 2,4,6-trimethylbenzaldehyde
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): 2,4,6-trimethylbenzaldehyde
- Appearance: colorless to faint yellow transparent liquid
- Storage condition: Refrigerator
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories Japan
- Age at study initiation: 5 weeks
- Weight at study initiation: 118 ± 3.1 g (males) and 94.9 ± 2.6 g (females)
- Fasting period before study: overnight
- Housing: Six to 10 animals were housed per cage (suspended metallic cages for rats) and reared on rat cage racks with automatic water supply syste.
- Diet: pellet food for rats MF (Oriental Yeast Co., Ltd.), ad libitum
- Water: tap water, ad libitum
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 ± 2
- Humidity (%): 55 ± 6
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0.25, 0.5, 2, 5 and 20 (w/v)%
MAXIMUM DOSE VOLUME APPLIED: 1.0 mL/100 g - Doses:
- 25, 50, 200, 500 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: General signs and symptoms: every day. Animals were weighed on Day 0 (day of administration), immediately before administration, and on Days 2, 7 and 14
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No male or female from any of the five groups died during the study period.
- Clinical signs:
- other: In the 25, 50, 200 and 500 mg/kg groups, no male showed any abnormality, while in the 2,000 mg/kg group, body drooping began to be seen about 20 min after administration. All six males in this group showed this change thereafter together with sedation. In
- Gross pathology:
- Necropsy conducted at the end of the study period in all surviving males and females from the 25, 50, 200, 500 and 2,000 mg/kg groups revealed no abnormality.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 was estimated to be >2000 mg/kg bw in both males and females.
- Executive summary:
In an acute oral toxicity study, performed according to OECD guideline 401, groups of 6 fasted Sprague-Dawley CD rats per sex per dose were treated once with the test substance at 0, 25, 50, 200, 500 and 2000 mg/kg dissolved in olive oil by oral gavage followed by a 14 -day observation period.All animals survived. In the 25, 50, 200 and 500 mg/kg groups, no abnormalities were observed. Signs of systemic toxicity noted during the study in the 2000 mg/kg bw dose group included body drooping, sedation, staggering, lacrimation, collapse, decrease in spontaneous locomotion, and slowing of breathing. Animals were without symptoms within 3 days. All animals showed expected gains in bodyweight over the study period, and no abnormalities were noted at necropsy. In conclusion, the acute oral LD50 of the test substance in Sprague-Dawley rat was estimated to be greater than 2000 mg/kg bodyweight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.