Registration Dossier
Registration Dossier
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EC number: 257-027-8 | CAS number: 51167-18-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP screening study
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
- Principles of method if other than guideline:
- Isolated eye chicken test
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2'-[2,4-dichloro-5-(1-methylethoxy)phenyl]-2,2-dimethylpropionohydrazide
- EC Number:
- 257-027-8
- EC Name:
- 2'-[2,4-dichloro-5-(1-methylethoxy)phenyl]-2,2-dimethylpropionohydrazide
- Cas Number:
- 51167-18-1
- Molecular formula:
- C14H20Cl2N2O2
- IUPAC Name:
- N'-(2,4-dichloro-5-isopropoxyphenyl)-2,2-dimethylpropanehydrazide
- Details on test material:
- - Name of test material (as cited in study report): 1-(2,4-dichloro 5-isopropoxy phenyl) 2-trimethylacetyl hydrazine (DIPTH)
- Storage condition of test material: stored in the dark at room temperature in air-tight containers
Constituent 1
Test animals / tissue source
- Species:
- other: Isolated chicken eye
Results and discussion
In vivo
- Irritant / corrosive response data:
- no indication of irritation to eyes
Any other information on results incl. tables
No further indication of the test results provided
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, 2'-[2,4-dichloro-5-(1-methylethoxy)phenyl]-2,2-dimethylpropionohydrazide is not classified as corrosive or severe irritant.
- Executive summary:
In an isolated eye chicken test performed in compliance with the GLP, 2'-[2,4-dichloro-5-(1-methylethoxy)phenyl]-2,2-dimethylpropionohydrazide (named as 1-(2,4-dichloro 5-isopropoxy phenyl) 2-trimethylacetyl hydrazine (DIPTH)) induced no irritation of the eyes. It can be therefore concluded that it is not classified as corrosive or severe irritant.
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