Registration Dossier
Registration Dossier
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EC number: 421-920-2 | CAS number: 154862-43-8
Neurotoxicity
Administrative data
Description of key information
- 28 day gavage NOAEL in hens > 1000 mg/kg bw/day (OECD 419)
- 13 week dietary NOAEL in rats > 363 mg/kg bw/day (FDA Redbook II, 1993)
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Evidence of neurotoxicity was not observed in a 28-day repeated dose delayed neurotoxicity study in the hen (OECD 419), or in a 13-week rat feeding study that included a functional observational battery and brain cholineserase measurement. Therefore, classification of Doverphos S-9228 is not justified according to the criteria described in Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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