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EC number: 226-641-8 | CAS number: 5444-75-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Sediment toxicity
Administrative data
Link to relevant study record(s)
Description of key information
No experimental data evaluating the toxicity to sediment organisms is available for 2-ethylhexyl benzoate (CAS No. 5444-75-4).Only negligible releases into surface waters from sewage treatment plants are expected to take place due to: a) the ready biodegradability and b) the high adsorption properties of this substance, resulting in an effective removal in sewage treatment plants. Therefore chronic exposure of sediment organisms is unlikely. This is confirmed by the outcome of the risk assessment (CSR 2018), that shows RCR values < 0.1 for sediment exposure. Furthermore, the substance is not toxic to aquatic organisms up to the limit of water solubility. In addition, available data indicate that 2-ethylhexyl benzoate is not bioaccumulative. Based on the available information, toxicity to sediment organisms is not expected to be of concern.
Key value for chemical safety assessment
Additional information
No experimental data evaluating the toxicity to sediment organisms is available for 2-ethylhexyl benzoate (CAS No. 5444-75-4). Only negligible releases into surface waters from sewage treatment plants are expected to take place due to:
a) the ready biodegradability (77% CO2 evolution in 28 days; Dickinson, 2008) and
b) the high adsorption properties of this substance, resulting in an effective removal in sewage treatment plants.
The substance exhibits a log Koc value of 4.07 and is poorly water soluble (0.4 mg/L).
The Guidance on information requirements and chemical safety assessment, Chapter R7.B (ECHA, 2017) states that once insoluble chemicals enter a standard STP, they will be extensively removed in the primary settling tank and fat trap and thus, only limited amounts will get in contact with activated sludge organisms. Nevertheless, once this contact takes place, these substances are expected to be removed from the water column to a significant degree by adsorption to sewage sludge (Guidance on information requirements and chemical safety assessment, Chapter R.7a, (ECHA, 2008)) and the rest will be extensively biodegraded (due to ready biodegradability). Therefore chronic exposure of sediment organisms is expected to be very low. This confirmed by the exposure calculations in the current risk assessment (CSR 2018). The risk assessment uses the equilibrium partitioning method to calculate the PNEC for toxicity towards sediment organisms. The outcome shows RCR values for risks towards sediment organisms < 0.1 for all exposure scenarios (these values are considered worst case as the risk characterisation ratio for sediment is multiplied by a factor of 10 to account for uncertainty due to the potential for adsorption based on the fact that the logKow is >5).
For sediment organisms rapid metabolism of 2-ethylhexyl benzoate is expected. After absorption, the substance is expected to be enzymatically hydrolysed in vivo by the enzyme carboxylesterase, yielding the corresponding alcohol and benzoic acid (Jones, 1956). Both hydrolysis products are supposed to be satisfactory metabolized in aquatic organisms. Therefore, no potential for bioaccumulation is to be expected.
The substance is not toxic to aquatic organisms up to the limit of water solubility. The performance of a long-term toxicity study to aquatic invertebrates has not been possible due to technical difficulties and as indicated above the exposure of the sediment is expected to be very low, therefore a study investigating toxicity of the substance towards sediment organisms is omitted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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